Salvatore De Fazio

TL;DR: The aim of the experiments was to determine, in the WAG/Rij model of absence epilepsy, if early long‐term treatment with some established antiabsence drugs might prevent the development of seizures, and whether such an effect could be sustained.

TL;DR: T careful review of the literature suggests that the available evidence does not support any causal relationship between use of risperidone or olanzapine and cardiovascular events, and this article focuses on some of the main adverse effects commonly reported during administration of atypical antipsychotics to elderly patients.

TL;DR: The effects of long‐term treatment with several AEDs on absence seizure development and onset of depressive‐like behavior in WAG/Rij rats at different ages are examined, using a forced swimming test (FST).

TL;DR: Prescription patterns were consistent with current evidence about the spectrum of efficacy of individual AEDs in different epilepsy syndromes, and the high prevalence of polytherapy, including combinations of three or more Aeds, is a cause for concern.

TL;DR: Clozapine treatment in the elderly requires a careful geriatric assessment and its use is strongly limited by the possibility of onset of severe adverse effects such as potentially fatal agranulocytosis, myocarditis and others such as seizures, weight gain and metabolic adverse effects.