Showing papers in "Epilepsy Research in 2010"

TL;DR: Overall, the odds of seizure freedom after surgery are two to three times higher in the presence of a lesion on histopathology or MRI, which is clinically and statistically significant, consistent across various subgroups, and quite homogeneous across studies.

TL;DR: The specific targeting of mitochondrial oxidative stress, dysfunction, and bioenergetics with pharmacological and non-pharmacological treatments may be a novel avenue for attenuating epileptogenesis.

TL;DR: The focus of the laboratory research is the study of the interaction of systemic inflammatory events with neuronal excitability and seizure susceptibility and possible mechanisms are discussed.

TL;DR: Treatment with once-daily eslicarbazepine acetate 800 mg and 1200 mg was more effective than placebo and generally well tolerated in patients with partial-onset seizures refractory to treatment with 1 to 3 concomitant AEDs.

TL;DR: The Tenth EILat Conference on New Antiepileptic Drugs (AEDs)-EILAT X, took place in Eilat, Israel from the 25th to 29th of April 2010, whose main themes included learning from the past and Detecting assessing and preventing adverse effects of AEDs.

TL;DR: A greater awareness, among clinicians, of the comorbidities between sleep disorders and epilepsy may help to prevent misdiagnosis and mistreatment, and sleep hygiene measures in epilepsy need to be more comprehensive.

TL;DR: In this paper, adverse effects of antiepileptic drugs (AEDs) in the developing mammalian brain are discussed, including interference with cell proliferation and migration, neurogenesis, axonal arborization, synaptogenesis, synaptic plasticity and physiological apoptotic cell death.

TL;DR: The demonstrated predictive ability of the corneal kindled mouse model supports its use in the early evaluation of investigational AEDs.

TL;DR: It is concluded that hemispherotomy can be performed successfully to treat medically intractable hemispheric epilepsy, providing remarkable results in terms of seizure outcome and quality of life.

TL;DR: Variations in the AQP4 and the KCNJ10/KCNJ9 region are likely to be associated with TLE, particularly TLE-FS, supporting the suggestion that perturbations of water and K(+) transport are involved in the etiopathogenesis of TLE.

TL;DR: High frequency hippocampal DBS at 130Hz is more effective than LFS (5Hz) in affecting excitability in epileptic rats, reflected in a higher AD threshold and longer AD latency during application of stimulation.

TL;DR: Pre and post resection ECoG correlated with its grade of severity and clinical outcome, and improvement in E coG correlated significantly with clinical improvement.

TL;DR: The first report implicating genetic variability in the A1AR with PTS, or any type of seizure disorder, is reported, providing a rationale for further studies investigating how adenosine neurotransmission impacts PTS, evaluating anticonvulsants in preventing and treating PTS, and developing and testing targeted adenosinergic therapies aimed at reducing PTS.

TL;DR: It is demonstrated that pretreatment with ganaxolone causes a dose-dependent suppression of behavioral and electrographic seizures in fully amygdala-kindled female mice, with nearly complete seizure protection at the highest dose tested.

TL;DR: This paper reports the first systematic review of uncommon causes of status epilepticus reported in the literature between 1990 and 2008, and identified 181 causes that were easily categorised into 5 specific aetiological categories.

TL;DR: The results provide the earliest indication of microstructural abnormality in cerebral white matter among children with idiopathic epilepsies and suggests disruption in myelination processes.

TL;DR: Despite a temporal reduction in seizure frequency with SC/PHT treatment, SC does not seem to be a suitable approach for anti-epileptogenic or anti-EPileptic therapy.

TL;DR: Damage to the cortex ipsilateral to the injury was more severe and extended more caudally in epileptic animals than in those without epilepsy, and the extent and location of cortical damage and its association with a lowered seizure threshold and the occurrence of spontaneous seizures were investigated.

TL;DR: The findings suggest that the DBA/2 mice are susceptible to RA, in part, because of the altered expression of 5-HT receptors, which are particularly important in regulating normal respiration.

TL;DR: It is shown that patient-specific, bivariate-synchrony-based seizure prediction could be random in general (under the assumption that channel-pair prediction times are statistically independent) and improvements in prediction performance should be achievable through investigations of multivariate synchrony combined with non-linear classification methods.

TL;DR: Clear phenomenological differences in the EEGs of both animal models suggest that these variables may represent basic phenotypic features of SWDs that should be sought after in the future studies that explore the genetic and molecular basis of absence epilepsy.

TL;DR: High-resolution HLA genotyping on patients affected by LTG-induced cADRs found HLA-B*1502 and other HLA alleles are not directly associated with LTg-induced MPE, and the possibility that Hla-B-1502 is associated with an increased risk ofLTG- induced SJS/TEN could not be excluded.

TL;DR: Results indicate that BRV is able to modulate the voltage-activated Na(+) inflow in cortical neurons, which conceivably might contribute to the antiepileptic activity of this drug.

TL;DR: By studying Granger causality and EEG coherence at the onset of SWD, the present review critically evaluates this theory based on the original data obtained in WAG/Rij rat model of absence epilepsy, and demonstrates that sleep spindles and spike-wave discharges are distinguished in time-frequency domain.

TL;DR: In adult LGS patients TS during sleep remain the major seizure type; moreover, a standard waking EEG may be normal; thus, polysomnography represents the most important mean of investigation also in adult L GS patients.

TL;DR: Increased negative connectivity in the patients as compared to controls across a network including thalamic, brainstem, frontal and parietal regions consistent with theories of inhibited function in subcortical and cortical structures during ictal propagation.

TL;DR: In the dose range of 400-1600mg/day, add-on rufinamide therapy may benefit patients with inadequately controlled partial seizures and is generally well tolerated, and higher doses may confer additional efficacy without adversely affecting safety and tolerability.

TL;DR: It is suggested that it is possible to reduce the number of epileptiform discharges in some patients by optimizing the fundamental tones and minimizing the higher frequency harmonics.

TL;DR: The data indicate that epilepsy surgery for partial seizures in children is associated with better quality of life as compared to children with intractable epilepsy who are not operated on, and suggest that in those who achieve seizure freedom normal QOL may at least potentially be possible.

TL;DR: The results suggest that an intense synaptic reorganization takes place in the epileptic hippocampus, including axonal sprouting of certain interneuron types, both in sclerotic and non-sclerotic tissue, which is a more general phenomenon of TLE than cell loss.