Sam W. Lee

TL;DR: The results show that the increased lifespan of ku80−/− MEFs owing to the loss of p21 is not associated with an improvement of the premature ageing phenotypes of kU80/− mice observed at the organismal level.

TL;DR: The human orthologue of Drosophila melanogaster ecdysoneless (hEcd) is identified as a novel p53-interacting protein that represents a novel regulator of p53 stability and function and the possibility that altered hEcd levels and/or function may contribute to oncogenesis.

TL;DR: This corrects the article to show that the method used to derive the H2O2 “spatially aggregating force” is a two-step process, rather than a single step, like in the previous version of this paper.

TL;DR: The findings indicate that the minimum number of events required for malignant transformation of human fibroblasts is greater than has been enumerated by such oncogene addition strategies and support a stochastic cancer progression model initiated by four defined cellular alterations.

TL;DR: A role of p53 in coordinating stress response with changes in cellular metabolism would help to bring a better understanding of how cancer cells acquire unique metabolic features to maintain their own survival and proliferation, and might provide interesting clues toward the development of novel therapies.