T
Takao Ide
Researcher at Saga University
Publications - 58
Citations - 2006
Takao Ide is an academic researcher from Saga University. The author has contributed to research in topics: Cancer & Hepatocellular carcinoma. The author has an hindex of 18, co-authored 50 publications receiving 1822 citations. Previous affiliations of Takao Ide include Harvard University.
Papers
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Journal ArticleDOI
Selective killing of cancer cells by a small molecule targeting the stress response to ROS
Lakshmi Raj,Takao Ide,Aditi U. Gurkar,Michael Foley,Monica Schenone,Xiaoyu Li,Nicola Tolliday,Todd R. Golub,Steven A. Carr,Alykhan F. Shamji,Andrew M. Stern,Anna Mandinova,Anna Mandinova,Stuart L. Schreiber,Sam W. Lee,Sam W. Lee +15 more
TL;DR: The ability of a small molecule to induce apoptosis selectively in cells that have a cancer genotypes is demonstrated, by targeting a non-oncogene co-dependency acquired through the expression of the cancer genotype in response to transformation-induced oxidative stress.
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Tumor–stromal cell interaction under hypoxia increases the invasiveness of pancreatic cancer cells through the hepatocyte growth factor/c‐Met pathway
Takao Ide,Yoshihiko Kitajima,Atsushi Miyoshi,Takao Ohtsuka,Mayumi Mitsuno,Kazuma Ohtaka,Yasuo Koga,Kohji Miyazaki +7 more
TL;DR: The results indicate that the hypoxic environment within stromal as well as cancer cells activates the HGF/c‐Met system, thereby contributing to the aggressive invasive features of pancreatic cancer.
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Induction of hepatocyte growth factor activator gene expression under hypoxia activates the hepatocyte growth factor/c‐Met system via hypoxia inducible factor‐1 in pancreatic cancer
TL;DR: Experiments demonstrated for the first time that HGFA is a novel HIF‐1 target gene, and under hypoxia, HGFA might be overexpressed and secreted from pancreatic cancer cells, which contributes to accelerate processing of HGF from fibroblast, resulting in the activation of the c‐Met pathway.
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The Hypoxic Environment in Tumor-Stromal Cells Accelerates Pancreatic Cancer Progression via the Activation of Paracrine Hepatocyte Growth Factor/c-Met Signaling
Takao Ide,Yoshihiko Kitajima,Atsushi Miyoshi,Takao Ohtsuka,Mayumi Mitsuno,Kazuma Ohtaka,Kohji Miyazaki +6 more
TL;DR: Data suggest that the HGF/c-Met signaling via HIF-1α may negatively affect the prognosis in patients with pancreatic cancer, and targeting tumor stroma under hypoxia might thus be potentially useful as a novel therapy for this cancer.
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GAMT, a p53-inducible modulator of apoptosis, is critical for the adaptive response to nutrient stress.
Takao Ide,Lauren Brown-Endres,Kiki Chu,Pat P. Ongusaha,Takao Ohtsuka,Wafik S. El-Deiry,Stuart A. Aaronson,Sam W. Lee,Sam W. Lee +8 more
TL;DR: In this paper, the p53 tumor suppressor protein has a well-established role in cell-fate decision-making processes and has been identified as a key downstream effector of adaptive response to nutrient stress.