S
Sam W. Lee
Researcher at Harvard University
Publications - 148
Citations - 22846
Sam W. Lee is an academic researcher from Harvard University. The author has contributed to research in topics: Cancer & DNA damage. The author has an hindex of 65, co-authored 148 publications receiving 19066 citations. Previous affiliations of Sam W. Lee include University of Michigan & Broad Institute.
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HB-EGF is a potent inducer of tumor growth and angiogenesis.
Pat P. Ongusaha,Jennifer C. Kwak,Andrew J. Zwible,Salvador Macip,Shigeki Higashiyama,Naoyuki Taniguchi,Li Fang,Sam W. Lee +7 more
TL;DR: Findings establish s-HB-EGF as a potent inducer of tumor growth and angiogenesis and suggest that therapeutic intervention aimed at the inhibition of s- HB- EGF functions may be useful in cancer treatment.
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p21Waf1/Cip1/Sdi1 induces permanent growth arrest with markers of replicative senescence in human tumor cells lacking functional p53.
TL;DR: Sustained p21Waf1/Cip1/Sdi1 induction sensitized EJ cells to apoptotic cell death induced by mitomycin C, a cross-linking DNA damaging agent, and these results imply that therapeutic intervention in human cancers might be aimed at sustained elevation of p 21Waf 1/CIP1/ Sdi1 expression.
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P53-mediated induction of Cox-2 counteracts p53- or genotoxic stress-induced apoptosis.
Jeong A. Han,Jong Il Kim,Pat P. Ongusaha,Daniel H. Hwang,Leslie R. Ballou,Alka Mahale,Stuart A. Aaronson,Sam W. Lee +7 more
TL;DR: Results demonstrate that Cox‐2 is induced by p53‐mediated activation of the Ras/Raf/ERK cascade, counteracting p 53‐mediated apoptosis, and this anti‐apoptosis effect may be a mechanism to abate cellular stresses associated with p53 induction.
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Identification of a Human VPF/VEGF 3′ Untranslated Region Mediating Hypoxia-induced mRNA Stability
Kevin P. Claffey,Shu-Ching Shih,Andrew Mullen,Suzan Dziennis,Jennifer L. Cusick,Kristin Abrams,Sam W. Lee,Michael Detmar +7 more
TL;DR: Increased VPF/VEGF mRNA stability induced by hypoxia is mediated, at least in part, by specific interactions between a defined mRNA stability sequence in the 3' untranslated region and distinct mRNA-binding proteins in human tumor cells.
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Transcriptional role of p53 in interferon-mediated antiviral immunity
César Muñoz-Fontela,Salvador Macip,Luis Martinez-Sobrido,Lauren Brown,Joseph Ashour,Adolfo García-Sastre,Adolfo García-Sastre,Sam W. Lee,Stuart A. Aaronson +8 more
TL;DR: The results demonstrate that p53 contributes to innate immunity by enhancing IFN-dependent antiviral activity independent of its functions as a proapoptotic and tumor suppressor gene.