Samantha L. Bailey

TL;DR: Analysis of activation of naive proteolipid protein (PLP)139–151-specific T cells in SJL mice undergoing PLP178–191-induced R-EAE or TMEV-IDD suggests that naive T cells enter the inflamed CNS and are activated by local APCs, possibly DCs, to initiate epitope spreading.

TL;DR: A critical function for CNS mDCs in driving relapses in relapsing EAE is indicated, and plasmacytoid DCs and CD8α+ DCs were superior to macrophages but were much less efficient in presenting endogenous peptide to induce TH-17 cells.

TL;DR: A role for DCs is indicated in the induction of antigen-specific CD4+CD25+Foxp3+ T cells that can inhibit fully developed autoimmunity in a nonlymphopoenic host, providing an important potential strategy for immunotherapy in patients with autoimmune diabetes.

TL;DR: It is reported that CNS delivery of IFN-gamma before EAE onset ameliorated the disease course and prevented demyelination, axonal damage, and oligodendrocyte loss and suggested that therapeutic approaches to activate the ISR could prove beneficial in MS.

TL;DR: The immunological elements of the healthy CNS and the pattern of responses that evolve during innate and adaptive immunity in this organ are discussed.