S
Sambamurthy Chandrasekaran
Researcher at University of Hyderabad
Publications - 21
Citations - 445
Sambamurthy Chandrasekaran is an academic researcher from University of Hyderabad. The author has contributed to research in topics: Visceral leishmaniasis & Toxoplasma gondii. The author has an hindex of 10, co-authored 18 publications receiving 324 citations. Previous affiliations of Sambamurthy Chandrasekaran include University of Arizona.
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Cytokines: Key determinants of resistance or disease progression in visceral leishmaniasis: Opportunities for novel diagnostics and immunotherapy
TL;DR: A comprehensive knowledge on the molecular interactions of immune cells or components and on cytokines interplay in the host defense or pathogenesis is important to determine appropriate immunotherapies for leishmaniasis.
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Impact of inflammation on male fertility.
Oli Sarkar,Jamila Bahrainwala,Sambamurthy Chandrasekaran,Shiva Kothari,Premendu P. Mathur,Ashok Agarwal +5 more
TL;DR: The correlations between inflammation and oxidative stress vis-à-vis spermatogenesis is reviewed and the implications of infections on male fertility/infertility and assisted reproductive technologies for the male are discussed.
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An in vitro study of apoptotic like death in Leishmania donovani promastigotes by withanolides
TL;DR: Results of this study indicate that withanolides induce apoptotic like death through the production of ROS from mitochondria and disruption of Ψm in promastigotes of L donovani.
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Leptin induces the phagocytosis and protective immune response in Leishmania donovani infected THP-1 cell line and human PBMCs.
TL;DR: Leptin is able to maintain the defensive environment against L. donovani infection through the classical macrophage activity and induces the macrophages phagocytic activity by enhancing the intracellular ROS generation which helps in phagolysosome formation and oxidative killing of the parasite.
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In vitro and in vivo evaluation of anti-leishmanial and immunomodulatory activity of Neem leaf extract in Leishmania donovani infection.
TL;DR: Ethyl acetate fraction (EAF) alone was found to exhibit leishmanicidal effect validated through cytotoxicity assay and estimated its IC₅₀ to be 52.4 µg/ml on the promastigote stage, and propidium iodide staining of dead cells substantiated the aforementioned activity.