A
Alti Dayakar
Researcher at University of Hyderabad
Publications - 11
Citations - 347
Alti Dayakar is an academic researcher from University of Hyderabad. The author has contributed to research in topics: Visceral leishmaniasis & Leptin. The author has an hindex of 8, co-authored 9 publications receiving 249 citations.
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Cytokines: Key determinants of resistance or disease progression in visceral leishmaniasis: Opportunities for novel diagnostics and immunotherapy
TL;DR: A comprehensive knowledge on the molecular interactions of immune cells or components and on cytokines interplay in the host defense or pathogenesis is important to determine appropriate immunotherapies for leishmaniasis.
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Biocompatible silver nanoparticles reduced from Anethum graveolens leaf extract augments the antileishmanial efficacy of miltefosine.
TL;DR: It is found that, AgNPs (between 20 and 100 μM) are biocompatible in nature through pertaining >80% viability of macrophages, and the enhanced antileishmanial activity of miltefosine with silver-nanoparticles synthesized by using Anethum graveolens (dill) leaf extract as reducing agent is studied.
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An in vitro study of apoptotic like death in Leishmania donovani promastigotes by withanolides
TL;DR: Results of this study indicate that withanolides induce apoptotic like death through the production of ROS from mitochondria and disruption of Ψm in promastigotes of L donovani.
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Leptin induces the phagocytosis and protective immune response in Leishmania donovani infected THP-1 cell line and human PBMCs.
TL;DR: Leptin is able to maintain the defensive environment against L. donovani infection through the classical macrophage activity and induces the macrophages phagocytic activity by enhancing the intracellular ROS generation which helps in phagolysosome formation and oxidative killing of the parasite.
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In vitro and in vivo evaluation of anti-leishmanial and immunomodulatory activity of Neem leaf extract in Leishmania donovani infection.
TL;DR: Ethyl acetate fraction (EAF) alone was found to exhibit leishmanicidal effect validated through cytotoxicity assay and estimated its IC₅₀ to be 52.4 µg/ml on the promastigote stage, and propidium iodide staining of dead cells substantiated the aforementioned activity.