S
Samuel R. Krimmel
Researcher at University of Maryland, Baltimore
Publications - 24
Citations - 506
Samuel R. Krimmel is an academic researcher from University of Maryland, Baltimore. The author has contributed to research in topics: Medicine & Claustrum. The author has an hindex of 9, co-authored 16 publications receiving 272 citations. Previous affiliations of Samuel R. Krimmel include Carleton College.
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Journal ArticleDOI
A Negative Allosteric Modulator for α5 Subunit-Containing GABA Receptors Exerts a Rapid and Persistent Antidepressant-Like Action without the Side Effects of the NMDA Receptor Antagonist Ketamine in Mice.
Panos Zanos,Mackenzie E. Nelson,Jaclyn N. Highland,Samuel R. Krimmel,Polymnia Georgiou,Todd D. Gould,Scott M. Thompson +6 more
TL;DR: This article showed that negative allosteric modulators of GABA-A receptors containing α5 subunits (α5 GABA-NAMs) should also promote high-frequency correlated electroencephalogram (EEG) activity and should therefore exert rapid antidepressant responses.
Journal ArticleDOI
Altered brain structure and function associated with sensory and affective components of classic trigeminal neuralgia.
TL;DR: Multiple lines of evidence are provided supporting aberrant structural and functional patterns that are observed in patients with CTN, which may help to better understand the pathophysiology of CTN and facilitate the development of new therapies for this disease.
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Psilocybin acutely alters the functional connectivity of the claustrum with brain networks that support perception, memory, and attention
Frederick S. Barrett,Samuel R. Krimmel,Roland R. Griffiths,David A. Seminowicz,Brian N. Mathur +4 more
TL;DR: This study uses a pharmacological intervention to provide the first empirical evidence in any species for a significant role of 5-HT2A receptor signaling in claustrum functioning, and supports a possible role of the claustrums in the subjective and therapeutic effects of psilocybin.
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Enhanced mindfulness-based stress reduction in episodic migraine: a randomized clinical trial with magnetic resonance imaging outcomes.
David A. Seminowicz,Shana A.B. Burrowes,A. Kearson,Jing Zhang,Samuel R. Krimmel,Luma Samawi,Andrew J. Furman,Michael L. Keaser,Neda F Gould,Trish Magyari,Linda W. White,Olga Goloubeva,Madhav Goyal,B. Lee Peterlin,Jennifer A. Haythornthwaite +14 more
TL;DR: There were no differences in clinical outcomes at 52 weeks or MRI outcomes at 20 weeks, although changes related to cognitive networks with MBSR+ were observed, suggesting MBSr+ is an effective treatment option for episodic migraine.
Journal ArticleDOI
Resting state functional connectivity and cognitive task-related activation of the human claustrum.
Samuel R. Krimmel,Michael G. White,Matthew H. Panicker,Frederick S. Barrett,Brian N. Mathur,David A. Seminowicz +5 more
TL;DR: It is suggested that the human claustrum can be functionally isolated with fMRI, and that it may play a role in cognitive control, and specifically task switching, independent of sensorimotor processing.