S
Sanaz Ghaffarian
Researcher at University of Utah
Publications - 3
Citations - 707
Sanaz Ghaffarian is an academic researcher from University of Utah. The author has contributed to research in topics: AAA proteins & ESCRT. The author has an hindex of 3, co-authored 3 publications receiving 682 citations.
Papers
More filters
Journal ArticleDOI
ESCRT-III recognition by VPS4 ATPases
Melissa D. Stuchell-Brereton,Jack J. Skalicky,Collin Kieffer,Mary Anne Karren,Sanaz Ghaffarian,Wesley I. Sundquist +5 more
TL;DR: These studies reveal how the VPS4 ATPases recognize their CHMP substrates to facilitate the membrane fission events required for the release of viruses, endosomal vesicles and daughter cells.
Journal ArticleDOI
Structural and mechanistic studies of VPS4 proteins.
Anna Scott,Hyo Young Chung,Malgorzata Gonciarz-Swiatek,Gina C. Hill,Frank G. Whitby,Jason Gaspar,James M. Holton,Ramya Viswanathan,Sanaz Ghaffarian,Christopher P. Hill,Wesley I. Sundquist +10 more
TL;DR: It is proposed that Vps4 proteins cycle between soluble, inactive low molecular weight complexes and active, membrane‐associated double‐ring structures that bind ATP and coassemble with LIP5/Vta1.
Journal ArticleDOI
The Human Endosomal Sorting Complex Required for Transport (ESCRT-I) and Its Role in HIV-1 Budding
Melissa D. Stuchell,Jennifer E. Garrus,Barbara Müller,Kirsten M. Stray,Sanaz Ghaffarian,Rena McKinnon,Hans-Georg Kräusslich,Scott G. Morham,Wesley I. Sundquist +8 more
TL;DR: Bioinformatics and yeast two-hybrid screening methods were used to identify four novel human proteins (VPS37A–D) that share weak but significant sequence similarity with yeast Vps37p and to demonstrate that V PS37A and VPS37B bind TSG101.