S
Sandra Castillo
Researcher at VTT Technical Research Centre of Finland
Publications - 35
Citations - 4798
Sandra Castillo is an academic researcher from VTT Technical Research Centre of Finland. The author has contributed to research in topics: Biology & Medicine. The author has an hindex of 14, co-authored 26 publications receiving 3696 citations. Previous affiliations of Sandra Castillo include University of Manitoba.
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MZmine 2: Modular framework for processing, visualizing, and analyzing mass spectrometry-based molecular profile data
TL;DR: A new generation of a popular open-source data processing toolbox, MZmine 2 is introduced, suitable for processing large batches of data and has been applied to both targeted and non-targeted metabolomic analyses.
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Novel Theranostic Opportunities Offered by Characterization of Altered Membrane Lipid Metabolism in Breast Cancer Progression
Mika Hilvo,Carsten Denkert,Laura Lehtinen,Berit Maria Müller,Scarlet F. Brockmöller,Tuulikki Seppänen-Laakso,Jan Budczies,Elmar Bucher,Laxman Yetukuri,Sandra Castillo,Emilia Berg,Heli Nygren,Marko Sysi-Aho,Julian L. Griffin,Oliver Fiehn,Sibylle Loibl,Christiane Richter-Ehrenstein,Cornelia Radke,Tuulia Hyötyläinen,Olli Kallioniemi,Kristiina Iljin,Matej Orešič +21 more
TL;DR: Analyzing the global lipid profiles of breast cancer, integrating the results to protein expression, and validate the findings by functional experiments imply that phospholipids may have diagnostic potential as well as that modulation of their metabolism may provide therapeutic opportunities in breast cancer treatment.
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Association of Lipidome Remodeling in the Adipocyte Membrane with Acquired Obesity in Humans
Kirsi H. Pietiläinen,Tomasz Róg,Tuulikki Seppänen-Laakso,Sam Virtue,Peddinti Gopalacharyulu,Jing Tang,Sergio Rodriguez-Cuenca,Arkadiusz Maciejewski,Arkadiusz Maciejewski,Jussi Naukkarinen,Jussi Naukkarinen,Anna-Liisa Ruskeepää,Perttu S. Niemelä,Laxman Yetukuri,Chong Yew Tan,Vidya Velagapudi,Sandra Castillo,Heli Nygren,Tuulia Hyötyläinen,Aila Rissanen,Jaakko Kaprio,Jaakko Kaprio,Hannele Yki-Järvinen,Ilpo Vattulainen,Ilpo Vattulainen,Ilpo Vattulainen,Antonio Vidal-Puig,Matej Orešič,Matej Orešič +28 more
TL;DR: In this paper, the authors performed lipidomic analyses of adipose tissue in twin pairs discordant for obesity but still metabolically compensated, and found that the observed lipid remodeling maintains the biophysical properties of lipid membranes, at the price of increasing their vulnerability to inflammation.
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Data analysis tool for comprehensive two-dimensional gas chromatography/time-of-flight mass spectrometry.
TL;DR: A method for efficient treatment of large data sets produced by GC×GC/TOFMS implemented as a freely available open source software package, Guineu, successfully used for the analysis of several thousand samples in the field of metabolomics is presented.
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Algorithms and tools for the preprocessing of LC–MS metabolomics data
TL;DR: This review presents an overview of selected software tools for preprocessing LC–MS based metabolomics data and tries to provide future directions.