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Sam Virtue
Researcher at University of Cambridge
Publications - 52
Citations - 3689
Sam Virtue is an academic researcher from University of Cambridge. The author has contributed to research in topics: Adipose tissue & Insulin resistance. The author has an hindex of 24, co-authored 43 publications receiving 3027 citations. Previous affiliations of Sam Virtue include National Institute for Health Research & Wellcome Trust.
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Journal ArticleDOI
Adipose tissue expandability, lipotoxicity and the Metabolic Syndrome — An allostatic perspective
Sam Virtue,Antonio Vidal-Puig +1 more
TL;DR: The links between adipokines, inflammation, adipose tissue expandability and lipotoxicity are discussed and how considering the concept of allostasis may enable a better understanding of how diabetes develops and allow the rational design of new anti diabetic treatments is discussed.
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PPAR gamma 2 Prevents Lipotoxicity by Controlling Adipose Tissue Expandability and Peripheral Lipid Metabolism
Gema Medina-Gomez,Sarah L. Gray,Laxman Yetukuri,Kenju Shimomura,Sam Virtue,Mark Campbell,R. Keira Curtis,Mercedes Jimenez-Linan,Margaret Blount,Giles S.H. Yeo,Miguel Ángel López,Tuulikki Seppänen-Laakso,Frances M. Ashcroft,Matej Orešič,Antonio Vidal-Puig +14 more
TL;DR: The results indicate that the PPARg2 isoform plays an important role, mediating adipose tissue expansion in response to positive energy balance, and may be required for the β-cell hypertrophic adaptive response to insulin resistance.
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GDF15 mediates the effects of metformin on body weight and energy balance
Anthony P. Coll,Michael Chen,Pranali Taskar,Debra Rimmington,Satish Patel,John Tadross,Irene Cimino,Ming Yang,Paul Welsh,Sam Virtue,Deborah A. Goldspink,Emily L. Miedzybrodzka,Adam R. Konopka,Raul Ruiz Esponda,Jeffrey T.-J. Huang,Y. C. Loraine Tung,Sergio Rodriguez-Cuenca,Rute A. Tomaz,Heather P. Harding,Audrey Melvin,Giles S.H. Yeo,David Preiss,Antonio Vidal-Puig,Ludovic Vallier,K. Sreekumaran Nair,Nicholas J. Wareham,David Ron,Fiona M. Gribble,Frank Reimann,Naveed Sattar,David B. Savage,Bernard B. Allan,Stephen O'Rahilly +32 more
TL;DR: It is shown—in two independent randomized controlled clinical trials—that metformin increases circulating levels of the peptide hormone growth/differentiation factor 15 (GDF15), which has been shown to reduce food intake and lower body weight through a brain-stem-restricted receptor.
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Association of Lipidome Remodeling in the Adipocyte Membrane with Acquired Obesity in Humans
Kirsi H. Pietiläinen,Tomasz Róg,Tuulikki Seppänen-Laakso,Sam Virtue,Peddinti Gopalacharyulu,Jing Tang,Sergio Rodriguez-Cuenca,Arkadiusz Maciejewski,Arkadiusz Maciejewski,Jussi Naukkarinen,Jussi Naukkarinen,Anna-Liisa Ruskeepää,Perttu S. Niemelä,Laxman Yetukuri,Chong Yew Tan,Vidya Velagapudi,Sandra Castillo,Heli Nygren,Tuulia Hyötyläinen,Aila Rissanen,Jaakko Kaprio,Jaakko Kaprio,Hannele Yki-Järvinen,Ilpo Vattulainen,Ilpo Vattulainen,Ilpo Vattulainen,Antonio Vidal-Puig,Matej Orešič,Matej Orešič +28 more
TL;DR: In this paper, the authors performed lipidomic analyses of adipose tissue in twin pairs discordant for obesity but still metabolically compensated, and found that the observed lipid remodeling maintains the biophysical properties of lipid membranes, at the price of increasing their vulnerability to inflammation.
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The Human Lipodystrophy Gene BSCL2/Seipin May Be Essential for Normal Adipocyte Differentiation
Victoria A. Payne,Neil Grimsey,Antoinette Tuthill,Sam Virtue,Sarah L. Gray,Edoardo Dalla Nora,Robert K. Semple,Stephen O'Rahilly,Justin J. Rochford +8 more
TL;DR: This study demonstrates that BSCL2 is an essential, cell-autonomous regulator of adipogenesis, and the induction of BSCL1 expression was essential for adipogenesis to occur.