S
Sandra Pacios
Researcher at University of Pennsylvania
Publications - 10
Citations - 696
Sandra Pacios is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Periodontitis & Bone resorption. The author has an hindex of 10, co-authored 10 publications receiving 585 citations. Previous affiliations of Sandra Pacios include International University Of Catalonia.
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Journal ArticleDOI
FOXO1 promotes wound healing through the up-regulation of TGF-β1 and prevention of oxidative stress.
Bhaskar Ponugoti,Fanxing Xu,Fanxing Xu,Chenying Zhang,Chenying Zhang,Chen Tian,Sandra Pacios,Sandra Pacios,Dana T. Graves +8 more
TL;DR: FOXO1 orchestrates wound healing through the up-regulation of TGF-β1 and protection against oxidative stress, which together act to promote keratinocyte migration and decrease apoptosis.
Journal ArticleDOI
Diabetes aggravates periodontitis by limiting repair through enhanced inflammation
Sandra Pacios,Jun Kang,Johnah C. Galicia,Kenneth Gluck,Hemal H. Patel,Amy Ovaydi-Mandel,Sofia D. Petrov,Faizan Alawi,Dana T. Graves +8 more
TL;DR: Diabetes prolongs inflammation and osteoclastogenesis in periodontitis and through TNF limits the normal reparative process by negatively modulating factors that regulate bone.
Book ChapterDOI
Cellular and Molecular Aspects of Bone Remodeling
TL;DR: Cells and mediators involved in the cellular and molecular machanisms of bone resorption and bone formation are discussed here.
Journal ArticleDOI
Osteoblast Lineage Cells Play an Essential Role in Periodontal Bone Loss Through Activation of Nuclear Factor-Kappa B.
Sandra Pacios,Wenmei Xiao,Wenmei Xiao,Marcelo Mattos,Jason C. Lim,Rohinton Tarapore,Sarah Alsadun,Bo Yu,Cun-Yu Wang,Dana T. Graves +9 more
TL;DR: It is demonstrated for the first time that osteoblast lineage cells play a critical role in periodontal disease through an NF-κB mediated mechanism that led to diminished osteoclast mediated bone resorption and greater coupled new bone formation.
Journal ArticleDOI
Aggregatibacter actinomycetemcomitans Infection Enhances Apoptosis In Vivo through a Caspase-3-Dependent Mechanism in Experimental Periodontitis
Jun Kang,Jun Kang,Beatriz de Brito Bezerra,Sandra Pacios,Sandra Pacios,Oelisoa M. Andriankaja,Yu Li,Vincent K. Tsiagbe,Helen Schreiner,Daniel H. Fine,Dana T. Graves +10 more
TL;DR: Results provide new insight into how diabetes aggravates A. actinomycetemcomitans-induced periodontal destruction in rats by significantly increasing the inflammatory response, leading to increased bone loss and enhancing apoptosis of gingival epithelial and connective tissue cells through a caspase-3-dependent mechanism.