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Sandrine Chabas
Researcher at University of Bordeaux
Publications - 15
Citations - 1498
Sandrine Chabas is an academic researcher from University of Bordeaux. The author has contributed to research in topics: Transcription (biology) & RNA. The author has an hindex of 10, co-authored 15 publications receiving 1396 citations. Previous affiliations of Sandrine Chabas include French Institute of Health and Medical Research.
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Journal ArticleDOI
The primary transcriptome of the major human pathogen Helicobacter pylori
Cynthia M. Sharma,Steve Hoffmann,Fabien Darfeuille,Fabien Darfeuille,Jérémy Reignier,Jérémy Reignier,Sven Findeiß,Alexandra Sittka,Sandrine Chabas,Sandrine Chabas,Kristin Reiche,Jörg Hackermüller,Richard Reinhardt,Peter F. Stadler,Jörg Vogel +14 more
TL;DR: A novel differential approach selective for the 5′ end of primary transcripts is presented, establishing a paradigm for mapping and annotating the primary transcriptomes of many living species and discovering hundreds of transcriptional start sites within operons, and opposite to annotated genes.
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Antisense oligonucleotides targeted to the domain IIId of the hepatitis C virus IRES compete with 40S ribosomal subunit binding and prevent in vitro translation
Béatrice Tallet‐Lopez,Lydia Aldaz-Carroll,Sandrine Chabas,Eric Dausse,Cathy Staedel,Jean-Jacques Toulmé +5 more
TL;DR: The antisense efficiency of the oligonucleotides was nicely correlated to their affinity for the IIId subdomain and to their ability to displace 40S ribosomal subunit, making this process a likely explanation for in vitro inhibition of HCV-IRES-dependent translation.
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Helicobacter pylori interferes with an embryonic stem cell micro RNA cluster to block cell cycle progression
Cedric Belair,Jessica Baud,Sandrine Chabas,Cynthia M. Sharma,Jörg Vogel,Cathy Staedel,Fabien Darfeuille +6 more
TL;DR: It is reported that Helicobacter pylori, a human stomach-colonizing bacterium responsible for severe gastric inflammatory diseases and gastric cancers, downregulates an embryonic stem cell microRNA cluster in proliferating gastric epithelial cells to achieve cell cycle arrest.
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Helicobacter pylori Initiates a Mesenchymal Transition through ZEB1 in Gastric Epithelial Cells
Jessica Baud,Christine Varon,Sandrine Chabas,Lucie Chambonnier,Fabien Darfeuille,Cathy Staedel +5 more
TL;DR: In gastric epithelial cells, cagPAI+ H. pylori activates NF-κB, which transactivates ZEB1, subsequently promoting mesenchymal transition, and the unexpected N-FκB-dependent increase of miR-200 levels likely thwarts the irreversible loss of epithelial identity in that critical situation.
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A promoter activity is present in the DNA sequence corresponding to the hepatitis C virus 5′ UTR
Estelle Dumas,Cathy Staedel,Marie Colombat,Sandrine Reigadas,Sandrine Chabas,Thérèse Astier-Gin,Annie Cahour,Simon Litvak,Michel Ventura +8 more
TL;DR: This work presents results suggesting the existence of a strong promoter activity carried by the DNA sequence corresponding to the HCV 5' UTR, and shows the unambiguous activity of such a promoter sequence in stably transfected cells.