Showing papers by "Sanford S. Elberg published in 1964"
TL;DR: The Brucella-immune histiocyte was found to be incapable of transferring its resistance to the cells of normal animals; it was also unable to achieve attenuation of virulent tubercle bacilli; and certain of its subcellular components (ribosomes and ribosomal RNA) were effective in inducing cellular resistance in normal animals against both BrucellA and mycobacteria.
Abstract: Comparison of the Brucella-immune and the BCG-immune histiocyte, each of which is resistant to necrotization by either Brucella or mycobacteria, has revealed a number of dissimilarities in their behavior. The Brucella-immune histiocyte was found to be incapable of transferring its resistance to the cells of normal animals; it was also unable to achieve attenuation of virulent tubercle bacilli. In contrast, the BCG-immune histiocyte and certain of its subcellular components (ribosomes and ribosomal RNA) were effective in inducing cellular resistance in normal animals against both Brucella and mycobacteria. When RNA was used, only immune ribosomal RNA was effective; when intact ribosomes were used, both immune and recipient ribosomes proved active. These investigations have also shown that the resistance of the BCG-immune histiocyte against Brucella and mycobacteria was of long duration and not readily dissociable.
9 citations
TL;DR: Inflammatory-induced peritoneal histiocytes of rabbit, guinea pig and monkey, both normal and immunized, respond to the cytotoxic action of parasitizing brucella within 24 hours, demonstrating cellular immunity produced by the Rev I strain of B. melitensis.
Abstract: SummaryInflammatory-induced peritoneal histiocytes of rabbit, guinea pig and monkey, both normal and immunized, respond to the cytotoxic action of parasitizing brucella within 24 hours. Normal cells undergo about 30% loss whereas immune cells resist completely the cytotoxic action for at least 96 hours and retard intracellular multiplication for at least 144 hours. Cells of rabbits, guinea pigs, and monkeys react alike in these respects. The cellular immunity produced by the Rev I strain of B. melitensis was also operative against virulent B. suis.
3 citations