S
Sangmok Kim
Researcher at University of California, Los Angeles
Publications - 10
Citations - 1156
Sangmok Kim is an academic researcher from University of California, Los Angeles. The author has contributed to research in topics: Synapse & Ubiquitin ligase. The author has an hindex of 8, co-authored 10 publications receiving 1070 citations. Previous affiliations of Sangmok Kim include Johns Hopkins University School of Medicine & UPRRP College of Natural Sciences.
Papers
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Journal ArticleDOI
Elongation Factor 2 and Fragile X Mental Retardation Protein Control the Dynamic Translation of Arc/Arg3.1 Essential for mGluR-LTD
Sungjin Park,Joo Min Park,Sangmok Kim,Jinah Kim,Jason D. Shepherd,Constance Smith-Hicks,Shoaib Chowdhury,Walter E. Kaufmann,Dietmar Kuhl,Alexey G. Ryazanov,Richard L. Huganir,David J. Linden,Paul F. Worley +12 more
TL;DR: It is demonstrated that Arc/Arg3.1 is translationally induced within 5 min of mGluR activation, and this response is essential for mGLUR-dependent LTD, and a model in which eEF2K-eEF2 and FMRP coordinately control the dynamic translation of Arc/ Arg3.
Journal ArticleDOI
Homeostatic Scaling Requires Group I mGluR Activation Mediated by Homer1a
Jia Hua Hu,Joo Min Park,Sungjin Park,Bo Xiao,Bo Xiao,Marlin H. Dehoff,Sangmok Kim,Takashi Hayashi,Martin K. Schwarz,Richard L. Huganir,Peter H. Seeburg,David J. Linden,Paul F. Worley +12 more
TL;DR: It is demonstrated that homeostatic scaling is dependent on group I metabotropic glutamate receptor activation that is mediated by the immediate early gene Homer1a, and an elegant interplay of mechanisms that underlie Hebbian and non-Hebbian plasticity is revealed.
Journal ArticleDOI
Synapse- and stimulus-specific local translation during long-term neuronal plasticity.
Dan Ohtan Wang,Sangmok Kim,Yali Zhao,Hongik Hwang,Satoru K. Miura,Wayne S. Sossin,Kelsey C. Martin +6 more
TL;DR: It is demonstrated, using translational reporters of sensorin mRNA expressed in individual cultured Aplysia sensory and motor neurons, that local translation occurs at synapses during transcription-dependent, learning-related forms of synaptic plasticity.
Journal ArticleDOI
Identification of a cis-acting element that localizes mRNA to synapses.
TL;DR: It is found that the export of sensorin mRNA from soma to neurite and the localization to synapse are controlled by distinct signals and a 66-nt element in the 5′ UTR of sensorsin is necessary and sufficient for synaptic mRNA localization.
Journal ArticleDOI
Neuron-wide RNA transport combines with netrin-mediated local translation to spatially regulate the synaptic proteome
Sangmok Kim,Kelsey C. Martin +1 more
TL;DR: Spatially restricting gene expression by regulating local translation rather than by directing the delivery of mRNAs from nucleus to stimulated synapses maximizes the readiness of the entire neuronal arbor to respond to local cues.