Showing papers by "Sanjay Kaul published in 2004"
TL;DR: It is suggested that the type of atherosclerotic lesions and the time of initiation during the course of lesion evolution modulate the beneficial effects of apoA-I–mimetic peptides on atherosclerosis.
Abstract: Background— Apolipoprotein (apo) A-I and apoA-I–mimetic peptides showed promise to prevent atherosclerosis development. Using a bypassed vein graft model in apoE-null mice, we evaluated the effects of oral or intraperitoneal administration of an apoA-I–mimetic peptide on evolving atherosclerotic lesions in the vein graft and compared such effects on the established atherosclerotic lesions in aortic sinus in the same mice. Methods and Results— We used apoE-null mice in which a segment of inferior vena cava was grafted into the right carotid artery at 16 weeks of age. Native aortic atherosclerotic lesions (established atherosclerosis) and vein-graft atherosclerotic lesions (evolving atherosclerosis) were assessed 4 weeks after daily oral (0.3 mg/mL) or intraperitoneal (50 μg in 200 μL saline) administration of an apoA-I–mimetic peptide, D4F. Mice receiving saline or water without D4F served as controls. Both oral and intraperitoneal administration of D4F reduced vein-graft atherosclerotic (evolving lesions)...
133 citations
TL;DR: The conventional approach to statistical inference is described, its limitations are highlighted, and an alternative approach based on Bayes' theorem is proposed, which is employed more widely in the design, analysis, and interpretation of clinical megatrials.
103 citations
TL;DR: A rapid improvement in endothelial dysfunction is indicated with a reduction in aortic cholesterol content and reduced platelet aggregability and occurred despite severe and persistent hypercholesterolemia.
76 citations
TL;DR: Increased arterial expression of iNOS, mediated at least in part by AhR signaling, may be an important mechanism by which CS increases carotid intimal thickening.
Abstract: Objective— We investigated the role of inducible NO synthase (iNOS) in intimal thickening with exposure to cigarette smoke (CS). Methods and Results— Intimal thickening in wild-type (WT) and iNOS-d...
40 citations