Evaluating Model Fit

Worldwide, some 240 million people have chronic hepatitis B virus (HBV), with the highest rates of infection in Africa and Asia. Our understanding of the natural history of HBV infection and the potential for therapy of the resultant disease is continuously improving. New data have become available since the previous APASL guidelines for management of HBV infection were published in 2012. The objective of this manuscript is to update the recommendations for the optimal management of chronic HBV infection. The 2015 guidelines were developed by a panel of Asian experts chosen by the APASL. The clinical practice guidelines are based on evidence from existing publications or, if evidence was unavailable, on the experts' personal experience and opinion after deliberations. Manuscripts and abstracts of important meetings published through January 2015 have been evaluated. This guideline covers the full spectrum of care of patients infected with hepatitis B, including new terminology, natural history, screening, vaccination, counseling, diagnosis, assessment of the stage of liver disease, the indications, timing, choice and duration of single or combination of antiviral drugs, screening for HCC, management in special situations like childhood, pregnancy, coinfections, renal impairment and pre- and post-liver transplant, and policy guidelines. However, areas of uncertainty still exist, and clinicians, patients, and public health authorities must therefore continue to make choices on the basis of the evolving evidence. The final clinical practice guidelines and recommendations are presented here, along with the relevant background information.

/pdf/asian-pacific-clinical-practice-guidelines-on-the-management-za5qxgu5i6.pdf

Asian-Pacific clinical practice guidelines on the management of hepatitis B: a 2015 update.

Swarm intelligence and bio-inspired algorithms form a hot topic in the developments of new algorithms inspired by nature. These nature-inspired metaheuristic algorithms can be based on swarm intelligence, biological systems, physical and chemical systems. Therefore, these algorithms can be called swarm-intelligence-based, bio-inspired, physics-based and chemistry-based, depending on the sources of inspiration. Though not all of them are efficient, a few algorithms have proved to be very effi cient and thus have become popular tools for solving real-world problems. Some algorithms are insuffici ently studied. The purpose of this review is to present a relatively comprehensive list of all the algorithms in the literature, so as to inspire further research.

/pdf/a-brief-review-of-nature-inspired-algorithms-for-7u733nqefl.pdf

A Brief Review of Nature-Inspired Algorithms for Optimization

Aggressive fungal pathogens such as Botrytis and Verticillium spp. cause severe crop losses worldwide. We recently discovered that Botrytis cinerea delivers small RNAs (Bc-sRNAs) into plant cells to silence host immunity genes. Such sRNA effectors are mostly produced by Botrytis cinerea Dicer-like protein 1 (Bc-DCL1) and Bc-DCL2. Here we show that expressing sRNAs that target Bc-DCL1 and Bc-DCL2 in Arabidopsis and tomato silences Bc-DCL genes and attenuates fungal pathogenicity and growth, exemplifying bidirectional cross-kingdom RNAi and sRNA trafficking between plants and fungi. This strategy can be adapted to simultaneously control multiple fungal diseases. We also show that Botrytis can take up external sRNAs and double-stranded RNAs (dsRNAs). Applying sRNAs or dsRNAs that target Botrytis DCL1 and DCL2 genes on the surface of fruits, vegetables and flowers significantly inhibits grey mould disease. Such pathogen gene-targeting RNAs represent a new generation of environmentally friendly fungicides.

/pdf/bidirectional-cross-kingdom-rnai-and-fungal-uptake-of-559u6ml7l7.pdf

Bidirectional cross-kingdom RNAi and fungal uptake of external RNAs confer plant protection

African vultures optimization algorithm: A new nature-inspired metaheuristic algorithm for global optimization problems

The present article reviews the historical and popular uses of garlic, its antioxidant, haematological, antimicrobial, hepatoprotective and antineoplastic properties and its potential toxicity (from sulfoxide). Garlic has been suggested to affect several cardiovascular risk factors. It has also been shown that garlic and its organic allyl sulfur components are effective inhibitors of the cancer process. Since garlic and its constituents can suppress carcinogen formation, bioactivation and tumour proliferation, it is imperative that biomarkers be established to identify which individuals might benefit most. Garlic powder, aged garlic and garlic oil have demonstrated antiplatelet and anticoagulant effects by interfering with cyclo-oxygenase-mediated thromboxane synthesis. Garlic has also been found to have synergistic effects against Helicobacter pylori with a proton pump inhibitor. The active compound allicin may affect atherosclerosis not only by acting as an antioxidant, but also by other mechanisms, such as lipoprotein modification and inhibition of LDL uptake and degradation by macrophages. Freshly prepared garlic homogenate protects against isoniazid+rifampicin-induced liver injury in experimental animal models. Several mechanisms are likely to account for this protection.

/pdf/garlic-in-health-and-disease-4fatdvzf4l.pdf

Garlic in health and disease.

Inactive carriers forms the largest group in chronic HBV infected patients. Around 300 million people are inactive carriers The inactive HBsAg carrier state is diagnosed by absence of HBeAg and presence of anti-HBe, undetectable or low levels of HBV DNA in PCR-based assays, repeatedly normal ALT levels, and minimal or no necroinflammation, slight fibrosis, or even normal histology on biopsy. Inactive cirrhosis may be present in patients who had active liver disease during the replicative phase of infection. The prognosis of the inactive HBsAg carrier state is usually benign. Long-term follow- up (up to 18 years) of these carriers has indicated that the vast majority show sustained biochemical remission and very low risk of cirrhosis or hepatocellular carcinoma (HCC). Rarely, patients, even noncirrhotics, may develop liver cancer during the inactive HBsAg carrier state. In addition, approximately 20 to 30% of persons in the inactive HBsAg carrier state may undergo spontaneous reactivation of hepatitis B during follow-up. Multiple episodes of reactivation or sustained reactivation can cause progressive hepatic damage and even hepatic decompensation. Introduction

/pdf/hepatitis-b-virus-inactive-carriers-3mumloljf4.pdf

Hepatitis B Virus: Inactive carriers

Emerging roles of melatonin in mitigating abiotic and biotic stresses of horticultural crops

In this paper we have introduced for the first time a new nature inspired meta-heuristics algorithm called Egyptian Vulture Optimization Algorithm which primarily favors combinatorial optimization problems. The algorithm is derived from the nature, behavior and key skills of the Egyptian Vultures for acquiring food for leading their livelihood. These spectacular, innovative and adaptive acts make Egyptian Vultures as one of the most intelligent of its kind among birds. The details of the bird’s habit and the mathematical modeling steps of the algorithm are illustrated demonstrating how the meta-heuristics can be applied for global solutions of the combinatorial optimization problems and has been studied on the traditional 0/1 Knapsack Problem (KSP) and tested for several datasets of different dimensions. The results of application of the algorithm on KSP datasets show that the algorithm works well w.r.t optimal value and provide the scope of utilization in similar kind of problems like path planning and other combinatorial optimization problems.

Egyptian Vulture Optimization Algorithm – A New Nature Inspired Meta-heuristics for Knapsack Problem

This paper describes changes in the circulating platelets of 25 patients with acute malaria within 2 to 6 days of onset of illness. Thrombocytopenia was observed in 10 out of 15 patients with Plasmodium falciparum infection, and in 4 out of 9 patients with P. vivax infection. One patient with a mixed infection of both species had a disseminated intravascular coagulation. Platelet antibody was detected in the sera of 8 out of 11 cases by the complement lysis inhibition technique and indirect immunofluorescence. The mean platelet antibody concentrations in the sera of 11 patients and 53 control subjects were 122.70 +/- 80.25 ng/10(7) platelets and 36.69 +/- 18.72 ng/10(7) platelets, respectively. An inverse relationship between the platelet count and platelet antibody levels in serum supported the view that thrombocytopenia in malaria may be partly immune-mediated. Platelet aggregation responses to agonists such as ADP, adrenaline, collagen and ristocetin revealed hyperactivity. Ultrastructural study of unstimulated platelets from patients revealed several changes such as centralization of dense granules, glycogen depletion, and formation of pseudopods and microaggregates, indicating in vivo activation of the platelets, which may also lead to thrombocytopenia.

Sanjeev Sharma

Papers

Garlic in health and disease.

Hepatitis B Virus: Inactive carriers

Emerging roles of melatonin in mitigating abiotic and biotic stresses of horticultural crops

Egyptian Vulture Optimization Algorithm – A New Nature Inspired Meta-heuristics for Knapsack Problem

Functional and ultrastructural changes of platelets in malarial infection.