S
Sankar Nath Sanyal
Researcher at Panjab University, Chandigarh
Publications - 110
Citations - 1757
Sankar Nath Sanyal is an academic researcher from Panjab University, Chandigarh. The author has contributed to research in topics: Apoptosis & Cyclooxygenase. The author has an hindex of 22, co-authored 110 publications receiving 1575 citations.
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PI3-kinase/Wnt association mediates COX-2/PGE(2) pathway to inhibit apoptosis in early stages of colon carcinogenesis: chemoprevention by diclofenac.
Jasmeet Kaur,Sankar Nath Sanyal +1 more
TL;DR: The study suggests that activation of PI3-kinase and Wnt signaling is associated with COX-2/PGE2 production and in turn inhibition of apoptosis in colon cancer, while diclofenac targeted these pathways to restore apoptosisIn the present system.
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Downregulation of PI3-K/Akt/PTEN pathway and activation of mitochondrial intrinsic apoptosis by Diclofenac and Curcumin in colon cancer.
Chandan Rana,Honit Piplani,Honit Piplani,Vivek Vaish,Vivek Vaish,Bimla Nehru,Sankar Nath Sanyal +6 more
TL;DR: Diclofenac and Curcumin showed anti-neoplastic effects by downregulating PI3-K/Akt/PTEN pathway, inducing apoptosis, increasing ROS generation, and decreasing ΔΨM.
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Upregulation of MAPK/Erk and PI3K/Akt pathways in ulcerative colitis-associated colon cancer
TL;DR: The morphological and histological investigation of the colonic samples from various animal groups revealed significant alterations as compared to the control in both inflammatory as well as carcinogenic conditions, and these effects were reduced to a large extent by the co-administration of celecoxib, a second-generation non-steroidal anti-inflammatory drug (NSAID).
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Antispermatogenic effect of embelin, a plant benzoquinone, on male albino rats in vivo and in vitro
TL;DR: Light and scanning electron microscopy showed that both in vivo and in vitro treatment with the drug causes profound morphological changes in spermatozoa such as decapitation of the spermatozosal head and alteration in the shape of the cytoplasmic droplet in the tail.
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Chemopreventive effects of NSAIDs on cytokines and transcription factors during the early stages of colorectal cancer
Vivek Vaish,Sankar Nath Sanyal +1 more
TL;DR: This study suggests that NSAIDs inhibit NF-κB and Jak3/Stat3 signaling and down-regulate pro-inflammatory cytokines to a level that inhibits inflammation and carcinogenesis.