S
Santasabuj Das
Researcher at Indian Council of Medical Research
Publications - 12
Citations - 192
Santasabuj Das is an academic researcher from Indian Council of Medical Research. The author has contributed to research in topics: Butyrate & Vibrio cholerae. The author has an hindex of 7, co-authored 12 publications receiving 171 citations.
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An adhesion protein of Salmonella enterica serovar Typhi is required for pathogenesis and potential target for vaccine development
Shubhamoy Ghosh,Krishnendu Chakraborty,Theeya Nagaraja,Surajit Basak,Hemanta Koley,Shanta Dutta,Utpala Mitra,Santasabuj Das +7 more
TL;DR: A 27-kDa outer membrane protein (T2544) plays a major role in bacterial adhesion to the host through high-affinity binding to laminin and is described as an adhesion protein of S. Typhi that contributes to bacterial pathogenesis.
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Evolutionary complexities of swine flu H1N1 gene sequences of 2009.
TL;DR: This study clearly suggests that strong purifying selection is responsible for the evolution of the novel influenza A (H1N1) virus among human and observes that the 2009 viral sequences are evolutionarily widely different from the past few years' sequences.
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Physiological TLR5 expression in the intestine is regulated by differential DNA binding of Sp1/Sp3 through simultaneous Sp1 dephosphorylation and Sp3 phosphorylation by two different PKC isoforms.
TL;DR: It is shown that butyrate transcriptionally upregulates TLR5 in the IECs and augments flagellin-induced immune responses and a novel insight is gained into Sp1/Sp3-mediated gene regulation that may apply to other genes.
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Caveolin-1 is transcribed from a hypermethylated promoter to mediate colonocyte differentiation and apoptosis.
TL;DR: It is reported for the first time that CAV1 expression was increased during colonocyte differentiation and mediated butyrate-induced differentiation and apoptosis of HT29 cells, and it is shown that HDAC inhibitor-mediated transactivation ofCAV1 was regulated by methylation density of the promoter.
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In silico approach towards identification of potential inhibitors of Helicobacter pylori DapE
TL;DR: A 3D model structure of H. pylorie DapE, which consisted of a catalytic domain and a dimerization domain generated by MODELLER software, is reported, which may provide a starting point to search for novel therapeutics.