Santosh K. Katiyar

TL;DR: Investigation of the role of a naturally occurring Pro-to-Ala substitution at amino acid position 660 (P660A), immediately distal to the highly conserved hot spot 1 region of Fks1p, in the reduced-echinocandin-susceptibility phenotype indicates that a Naturally occurring P660A substitution from the C. parapsilosis group accounts for the reduced susceptibility phenotype.

TL;DR: In vitro susceptibility data for Trichomonas vaginalis and G. lamblia is presented and in vitro activity of benzimidazoles against additional protozoan parasites is examined: little or no activity was observed against Entamoeba histolytica, Leishmania major, and AcanthamoebA polyphaga.

TL;DR: Phylogenetic analysis of rRNA sequences from these amitochondrial organisms suggests that G. lamblia, T. vaginalis, and microsporidia are near the base of the eukaryotic tree, while E. histolytica clusters with mitochondria-containing species.

TL;DR: It is reported that the mutation F641Y is associated with RES in a C. albicans isolate, and Y641-equivalent Fks residues were identified in intrinsically RES Fusarium species and Candida guilliermondii.

TL;DR: Evidence is presented that azole activity versus Saccharomyces cerevisiae is also modulated by Ca2+‐regulated signalling, and a model to explain the role of Ca2-regulated signalling in azole/terbinafine tolerance is proposed.