S
Sara Cohen
Researcher at Israel Institute for Biological Research
Publications - 45
Citations - 1547
Sara Cohen is an academic researcher from Israel Institute for Biological Research. The author has contributed to research in topics: Yersinia pestis & Virulence. The author has an hindex of 19, co-authored 45 publications receiving 1509 citations.
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Journal ArticleDOI
Substrate inhibition of acetylcholinesterase: residues affecting signal transduction from the surface to the catalytic center.
Avigdor Shafferman,Baruch Velan,Arie Ordentlich,C. Kronman,Haim Grosfeld,M Leitner,Yehuda Flashner,Sara Cohen,Dov Barak,Naomi Ariel +9 more
TL;DR: It is proposed that binding of acetylcholine, on the surface of AChE, may trigger sequence of conformational changes extending from the peripheral anionic site through W286 to D74, at the entrance of the ‘gorge’, and down to the catalytic center (through Y341 to F338 and Y337).
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Mutagenesis of human acetylcholinesterase. Identification of residues involved in catalytic activity and in polypeptide folding.
Avigdor Shafferman,C. Kronman,Yehuda Flashner,M Leitner,Haim Grosfeld,Arie Ordentlich,Yehoshua Gozes,Sara Cohen,Naomi Ariel,Dov Barak +9 more
TL;DR: The x-ray structure of the Torpedo acetylcholinesterase supports this assumption by revealing the participation of these residues in salt bridges between neighboring secondary structure elements.
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Generation of Yersinia pestis attenuated strains by signature-tagged mutagenesis in search of novel vaccine candidates.
Yehuda Flashner,Emanuelle Mamroud,T. Avital Tidhar,Raphael Ber,Moshe Aftalion,David Gur,Shirley Lazar,Anat Zvi,Tamar Bino,Naomi Ariel,Baruch Velan,Avigdor Shafferman,Sara Cohen +12 more
TL;DR: A signature-tagged mutagenesis strategy was used and optimized for a subcutaneously infected mouse model, resulting in selection of 16 mutant strains that were undetectable in spleens 48 h postinfection and was superior to the EV76 live vaccine strain.
Journal ArticleDOI
The effect of elimination of intersubunit disulfide bonds on the activity, assembly, and secretion of recombinant human acetylcholinesterase. Expression of acetylcholinesterase Cys-580----Ala mutant.
Baruch Velan,Haim Grosfeld,C. Kronman,M Leitner,Yehoshua Gozes,Arye Lazar,Yehuda Flashner,Dino Marcus,Sara Cohen,Avigdor Shafferman +9 more
TL;DR: The mutation did not seem to affect the efficiencies of either synthesis or secretion of recombinant HuAChE polypeptides, as was demonstrated in cell lines derived from human embryonic kidney as well as from a human neuroblastoma.
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The solute-binding component of a putative Mn(II) ABC transporter (MntA) is a novel Bacillus anthracis virulence determinant.
Orit Gat,Itai Mendelson,Theodor Chitlaru,Naomi Ariel,Zeev Altboum,Haim Levy,Shay Weiss,Haim Grosfeld,Sara Cohen,Avigdor Shafferman +9 more
TL;DR: It is proposed that MntA is a novel B.’anthracis virulence determinant essential for the development of anthrax disease, and that B. anthracisΔmntA strains have the potential to serve as platform for future live attenuated vaccines.