S
Sara Letizia Maria Eramo
Researcher at Catholic University of the Sacred Heart
Publications - 15
Citations - 734
Sara Letizia Maria Eramo is an academic researcher from Catholic University of the Sacred Heart. The author has contributed to research in topics: Oxidative stress & Ototoxicity. The author has an hindex of 13, co-authored 15 publications receiving 623 citations. Previous affiliations of Sara Letizia Maria Eramo include The Catholic University of America & Sapienza University of Rome.
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Journal ArticleDOI
Noise-induced hearing loss (NIHL) as a target of oxidative stress-mediated damage: cochlear and cortical responses after an increase in antioxidant defense.
Anna Rita Fetoni,Paola De Bartolo,Sara Letizia Maria Eramo,Rolando Rolesi,Fabiola Paciello,Christian Bergamini,Romana Fato,Gaetano Paludetti,Laura Petrosini,Diana Troiani +9 more
TL;DR: Findings indicate that antioxidant treatment restores auditory cortical neuronal morphology and hearing function by reducing the noise-induced redox imbalance in the cochlea and the deafferentation effects upstream the acoustic pathway.
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In vivo protective effect of ferulic acid against noise-induced hearing loss in the guinea-pig
Anna Rita Fetoni,Cesare Mancuso,Sara Letizia Maria Eramo,Massimo Ralli,Roberto Piacentini,Eugenio Barone,Gaetano Paludetti,Diana Troiani +7 more
TL;DR: Functional in vivo evidence that FA limits noise-induced hearing loss is provided and the antioxidant properties of FA as free-radical scavenger are confirmed and a role of HO-1 as an additional mediator against noise- induced ototoxicity is suggested.
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Molecular targets for anticancer redox chemotherapy and cisplatin-induced ototoxicity: the role of curcumin on pSTAT3 and Nrf-2 signalling.
Anna Rita Fetoni,Fabiola Paciello,Daniele Mezzogori,Rolando Rolesi,Sara Letizia Maria Eramo,Gaetano Paludetti,Diana Troiani +6 more
TL;DR: This study demonstrates that curcumin attenuates all stages of tumour progression and, by targeting pSTAT3 and Nrf-2 signalling pathways, provides chemosensitisation to cisplatin in vitro and protection from its ototoxic adverse effects in vivo.
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Rosmarinic acid up-regulates the noise-activated Nrf2/HO-1 pathway and protects against noise-induced injury in rat cochlea.
Anna Rita Fetoni,Fabiola Paciello,Rolando Rolesi,Sara Letizia Maria Eramo,Cesare Mancuso,Diana Troiani,Gaetano Paludetti +6 more
TL;DR: The herb-derived phenol rosmarinic acid (RA) attenuates noise-induced hearing loss, reducing threshold shift, and promotes hair cell survival, and enhances the endogenous antioxidant defenses, as shown by decreased superoxide production, reduced expression of 4-HNE, and up-regulation of SODs.
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Curcuma longa (curcumin) decreases in vivo cisplatin-induced ototoxicity through heme oxygenase-1 induction.
Anna Rita Fetoni,Sara Letizia Maria Eramo,Fabiola Paciello,Rolando Rolesi,Maria Vittoria Podda,Diana Troiani,Gaetano Paludetti +6 more
TL;DR: This preclinical study demonstrates that systemic curcumin attenuates ototoxicity and provides molecular evidence for a role of HO-1 as an additional mediator in attenuating cisplatin-induced damage.