Journal ArticleDOI
Rosmarinic acid up-regulates the noise-activated Nrf2/HO-1 pathway and protects against noise-induced injury in rat cochlea.
Anna Rita Fetoni,Fabiola Paciello,Rolando Rolesi,Sara Letizia Maria Eramo,Cesare Mancuso,Diana Troiani,Gaetano Paludetti +6 more
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TLDR
The herb-derived phenol rosmarinic acid (RA) attenuates noise-induced hearing loss, reducing threshold shift, and promotes hair cell survival, and enhances the endogenous antioxidant defenses, as shown by decreased superoxide production, reduced expression of 4-HNE, and up-regulation of SODs.About:
This article is published in Free Radical Biology and Medicine.The article was published on 2015-08-01. It has received 90 citations till now. The article focuses on the topics: Reactive oxygen species & Oxidative stress.read more
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Panax ginseng and Panax quinquefolius: From pharmacology to toxicology.
TL;DR: The aim of this review is to provide a simple and extensive overview of the pharmacokinetics and pharmacodynamics of P. ginseng and P. quinquefolius, focusing on the clinical evidence which has shown particular effectiveness in specific diseases, such as dementia, diabetes mellitus, respiratory infections, and cancer.
Journal ArticleDOI
The Neuroprotective Effects of Phenolic Acids: Molecular Mechanism of Action
TL;DR: In this review, the role of phenolic acids in ameliorating depression, ischemia/reperfusion injury, neuroinflammation, apoptosis, glutamate-induced toxicity, epilepsy, imbalance after traumatic brain injury, hyperinsulinemia-induced memory impairment, hearing and vision disturbances, Parkinson’s disease, Huntington's disease, anti-amyotrophic lateral sclerosis, Chagas disease and other less distributed diseases is discussed.
Journal ArticleDOI
The adverse effects of environmental noise exposure on oxidative stress and cardiovascular risk
Thomas Münzel,Mette Sørensen,Frank P. Schmidt,Erwin R. Schmidt,Sebastian Steven,Swenja Kröller-Schön,Andreas Daiber +6 more
TL;DR: An overview of epidemiological, translational clinical, and preclinical noise research addressing the nonauditory, adverse effects of noise exposure with focus on oxidative stress is provided.
Journal ArticleDOI
Berberine protects against 6-OHDA-induced neurotoxicity in PC12 cells and zebrafish through hormetic mechanisms involving PI3K/AKT/Bcl-2 and Nrf2/HO-1 pathways.
Chao Zhang,Chuwen Li,Shenghui Chen,Zhiping Li,Xuejing Jia,Kai Wang,Jiaolin Bao,Yeer Liang,Xiaotong Wang,Meiwan Chen,Peng Li,Huanxing Su,Jian-Bo Wan,Simon Ming-Yuen Lee,Kechun Liu,Chengwei He +15 more
TL;DR: The results demonstrated that BBR induced a typical hormetic response in PC12 cells, and strongly suggested that the neuroprotection of BBR were attributable to the hormetic mechanisms via activating cell survival and antioxidant signaling pathways.
Journal ArticleDOI
Therapeutic Potential of Rosmarinic Acid: A Comprehensive Review
Muhammad Nadeem,Muhammad Imran,Tanweer Aslam Gondal,Ali Imran,Muhammad Shahbaz,Rai Muhammad Amir,Muhammad Wasim Sajid,Tahira Batool Qaisrani,Muhammad Atif,Ghulam Hussain,Bahare Salehi,Elise Adrian Ostrander,Miquel Martorell,Javad Sharifi-Rad,William C. Cho,Natália Martins +15 more
TL;DR: Given the current evidence, RA may be considered as part of the daily diet in the treatment of several diseases, with pre-determined doses avoiding cytotoxicity, and its therapeutic potential against a wide variety of diseases is deliberate.
References
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Book
Free radicals in biology and medicine
TL;DR: 1. Oxygen is a toxic gas - an introduction to oxygen toxicity and reactive species, and the chemistry of free radicals and related 'reactive species'
Journal ArticleDOI
Structure-antioxidant activity relationships of flavonoids and phenolic acids
TL;DR: The factors underlying the influence of the different classes of polyphenols in enhancing their resistance to oxidation are discussed and support the contention that the partition coefficients of the flavonoids as well as their rates of reaction with the relevant radicals define the antioxidant activities in the lipophilic phase.
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Mitochondrial Reactive Oxygen Species (ROS) and ROS-Induced ROS Release
TL;DR: The mechanism of mitochondrial RIRR highlights the central role of mitochondria-formed ROS, and all of the known ROS-producing sites and their relevance to the mitochondrial ROS production in vivo are discussed.
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Heme oxygenase-1/carbon monoxide: from basic science to therapeutic applications.
TL;DR: The molecular and biochemical characterization of HOs is reviewed, with a discussion on the mechanisms of signal transduction and gene regulation that mediate the induction of HO-1 by environmental stress, to lay a foundation for potential future clinical applications of these systems.
Journal ArticleDOI
Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants
Albena T. Dinkova-Kostova,W. David Holtzclaw,Robert N. Cole,Ken Itoh,Nobunao Wakabayashi,Yasutake Katoh,Masayuki Yamamoto,Paul Talalay +7 more
TL;DR: This finding suggests that reaction of cysteine thiols is followed by rapid formation of protein disulfide linkages, which are the direct sensors of inducers of the phase 2 system.