S
Sara Piccinin
Publications - 29
Citations - 4076
Sara Piccinin is an academic researcher. The author has contributed to research in topics: Cell cycle & Carcinogenesis. The author has an hindex of 23, co-authored 28 publications receiving 3846 citations.
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Journal ArticleDOI
A "twist box" code of p53 inactivation: twist box: p53 interaction promotes p53 degradation.
Sara Piccinin,Elena Tonin,Sara Sessa,Silvia Demontis,Sabrina Rossi,Lorenza Pecciarini,Lucia Zanatta,Flavia Pivetta,Alessandra Grizzo,Maura Sonego,Camillo Rosano,Angelo Paolo Dei Tos,Claudio Doglioni,Roberta Maestro +13 more
TL;DR: This study suggests the existence of a Twist box code of p53 inactivation and provides the proof of principle that targeting the Twist box:p53 interaction might offer additional avenues for cancer treatment.
Journal Article
Tumor suppressor genes and related molecules in leiomyosarcoma.
A. P. Dei Tos,Roberta Maestro,Claudio Doglioni,Sara Piccinin,D. Della Libera,M. Boiocchi,Christopher D.M. Fletcher +6 more
TL;DR: The Rb-cyclin D pathway emerges as the preferred target for molecular abnormalities in this subset of soft tissue sarcomas and contrasts with the higher rates of p53/MDM2 abnormalities reported in other types of sarcoma.
Journal Article
Chromosome 13q deletion mapping in head and neck squamous cell carcinomas : identification of two distinct regions of preferential loss
Roberta Maestro,Sara Piccinin,Claudio Doglioni,Daniela Gasparotto,Tamara Vukosavljevic,Sandro Sulfaro,Luigi Barzan,Mauro Boiocchi +7 more
TL;DR: The data suggest the existence of two new tumor suppressor genes (one close to and one distal to RB), which play a role in the development and/or progression of head and neck squamous cell carcinomas.
Journal ArticleDOI
Molecular abnormalities of the p53 pathway in dedifferentiated liposarcoma.
Angelo Paolo Dei Tos,Claudio Doglioni,Sara Piccinin,Roberta Maestro,Thomas Mentzel,Mattia Barbareschi,Mauro Boiocchi,Christopher D.M. Fletcher +7 more
TL;DR: The results indicate that the p53 gene is rarely involved in dedifferentiated liposarcoma and that low percentages of p53 immunopositivity are still compatible with integrity of the p 53 gene.
Journal ArticleDOI
p16/CDKN2 and CDK4 gene mutations in sporadic melanoma development and progression
Sara Piccinin,Claudio Doglioni,Roberta Maestro,Tamara Vukosavijevic,Daniela Gasparotto,Claudia D'Orazi,Mauro Boiocchi +6 more
TL;DR: The absence of the CDKN2 mutation detected in the corresponding primary tumors suggests that 9p21 homozygous deletion may play a major role in the metastatic spreading of this type of tumor, and none of the cases analyzed showed the presence of an Arg24Cys mutation, which functionally protects CDK4 from p16 inhibition.