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Sara Tomičić

Researcher at Linköping University

Publications -  7
Citations -  537

Sara Tomičić is an academic researcher from Linköping University. The author has contributed to research in topics: Food allergy & Immunoglobulin A. The author has an hindex of 6, co-authored 7 publications receiving 493 citations.

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Influence of early gut microbiota on the maturation of childhood mucosal and systemic immune responses

TL;DR: Among sensitized infants, those with high, as compared with low levels, of salivary secretory IgA are less likely to develop allergic symptoms and early colonization with certain gut microbiota, e.g. Lactobacilli and Bifidobacterium species, might be associated with less allergy development.
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High levels of IgG4 antibodies to foods during infancy are associated with tolerance to corresponding foods later in life.

TL;DR: Investigation of the effect of elimination diet on serum and salivary antibodies and immunological parameters related to the ability to tolerate foods found eczematous, food sensitized infants with high levels of IgG4 and high ratios of IgE antibodies to food allergens are more likely to consume these foods at 4½ yr than infants with low levels and ratios.
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Breast milk cytokine and IgA composition differ in Estonian and Swedish mothers-relationship to microbial pressure and infant allergy.

TL;DR: Estonian mothers have lower breast milk levels of TGF-β, particularly T GF-β2, but higher levels of SIgA, IL-10, and IFN-γ than Swedish mothers, possibly because of differences in microbial load.
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Slow salivary secretory IgA maturation may relate to low microbial pressure and allergic symptoms in sensitized children.

TL;DR: Postnatal maturation of the salivary SIgA system proceeds markedly slower in Swedish than Estonian children, possibly as a consequence of low microbial pressure, which may limit allergy-mediated tissue damage at mucosal surfaces in sensitized individuals.
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Significant improvement of eczema with skin care and food elimination in small children.

TL;DR: Evaluating common methods of investigation and treatment in children younger than 2 y of age with eczema, with or without sensitization to food allergens, found that a subgroup improved their Eczema significantly without elimination diet.