Influence of early gut microbiota on the maturation of childhood mucosal and systemic immune responses
Ylva Margareta Sjögren,Sara Tomičić,Anna Lundberg,Malin Fagerås Böttcher,Bengt Björkstén,Eva Sverremark-Ekström,Maria C. Jenmalm +6 more
TLDR
Among sensitized infants, those with high, as compared with low levels, of salivary secretory IgA are less likely to develop allergic symptoms and early colonization with certain gut microbiota, e.g. Lactobacilli and Bifidobacterium species, might be associated with less allergy development.Abstract:
Introduction: Among sensitized infants those with high, as compared with low levels, of salivary secretory IgA (SIgA) are less likely to develop allergic symptoms. Also, early colonization with cer ...read more
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The Microbiota-Gut-Brain Axis
John F. Cryan,Kenneth J. O’Riordan,Caitlin S. M. Cowan,Kiran V. Sandhu,Thomaz F.S. Bastiaanssen,Marcus Boehme,Martín Gabriel Codagnone,Sofia Cussotto,Christine Fülling,Anna V. Golubeva,Katherine E. Guzzetta,Minal Jaggar,Caitriona M. Long-Smith,Joshua M. Lyte,Jason A. Martin,Alicia Molinero-Perez,Gerard M. Moloney,Emanuela Morelli,Enrique Morillas,Rory C. O'Connor,Joana S Cruz-Pereira,Veronica L. Peterson,Kieran Rea,Nathaniel L. Ritz,Eoin Sherwin,Simon Spichak,Emily M. Teichman,Marcel van de Wouw,Ana Paula Ventura-Silva,Shauna E. Wallace-Fitzsimons,Niall P. Hyland,Gerard Clarke,Timothy G. Dinan +32 more
TL;DR: Future studies will focus on understanding the mechanisms underlying the microbiota-gut-brain axis and attempt to elucidate microbial-based intervention and therapeutic strategies for neuropsychiatric disorders.
Journal ArticleDOI
Tryptophan Catabolites from Microbiota Engage Aryl Hydrocarbon Receptor and Balance Mucosal Reactivity via Interleukin-22
Teresa Zelante,Rossana G. Iannitti,Cristina Cunha,Antonella De Luca,Gloria Giovannini,Giuseppe Pieraccini,Riccardo Zecchi,Carmen D'Angelo,Cristina Massi-Benedetti,Francesca Fallarino,Agostinho Carvalho,Paolo Puccetti,Luigina Romani +12 more
TL;DR: A metabolic pathway whereby Trp metabolites from the microbiota balance mucosal reactivity in mice is described, whereby highly adaptive lactobacilli are expanded and produce an aryl hydrocarbon receptor (AhR) ligand-indole-3-aldehyde-that contributes to AhR-dependent Il22 transcription.
Journal ArticleDOI
The composition of the gut microbiota throughout life, with an emphasis on early life.
Juan M. Rodríguez,Kiera Murphy,Catherine Stanton,R. Paul Ross,Olivia I. Kober,Nathalie Juge,Ekaterina Avershina,Knut Rudi,Arjan Narbad,Maria C. Jenmalm,Julian Marchesi,Maria Carmen Collado +11 more
TL;DR: A review discusses recent studies on the early colonization and factors influencing this process which impact on health and an adequate establishment of microbiota and its maintenance throughout life would reduce the risk of disease in early and late life.
Journal ArticleDOI
Diet-Induced Dysbiosis of the Intestinal Microbiota and the Effects on Immunity and Disease
TL;DR: The role of the microbiota and the potential for diet-induced dysbiosis in inflammatory conditions of the GI tract and systemic diseases will be discussed.
Journal ArticleDOI
Low Gut Microbiota Diversity in Early Infancy Precedes Asthma at School Age
Thomas Abrahamsson,Hedvig E. Jakobsson,Anders F. Andersson,Bengt Björkstén,Bengt Björkstén,Lars Engstrand,Lars Engstrand,Maria C. Jenmalm +7 more
TL;DR: Low total diversity of the gut microbiota during the first year of life is associated with allergic diseases in infancy, but little is known how early microbial diversity is related to allergic disease later in school age.
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