Sarah A. Seay

TL;DR: Exposure to ULD aerosols leads to infection in a subset of mice, and to persistently low organ CFU, and may be used to identify host or bacterial factors that modulate the initial infection event.

TL;DR: Overall, this work identified the early interactions between Francisella and the host following two different routes of inoculation and identified alveolar macrophages as the first cell type infected in the lungs of mice intranasally inoculated with F. tularensis.

TL;DR: Dose retention efficiency and viable aerosol retention rate were calculated from the sampler titers to determine the efficiency of microbe retention in lungs of mice based on dose presented and respirable particle size.

TL;DR: In this article, the authors describe a method for the development of large recombinant BCG accession lots which stably express the lentiviral antigens, human immunodeficiency virus (HIV) gp120 and simian immunodiciency virus(SIV) Gag, using selectable leucine auxotrophic complementation.

TL;DR: Investigation of the effects of two known nuclear genome mutagens, cadmium and Aflatoxin B1, on germline mtDNA mutagenesis in Caenorhabditis elegans found there was no effect of either exposure on mtDNA mutation frequency, spectrum, or trinucleotide context signature despite a significant increase in nuclear mutation rate after aflat toxin B1 exposure.