S
Steven A. Porcelli
Researcher at Albert Einstein College of Medicine
Publications - 305
Citations - 30068
Steven A. Porcelli is an academic researcher from Albert Einstein College of Medicine. The author has contributed to research in topics: Antigen & Natural killer T cell. The author has an hindex of 91, co-authored 301 publications receiving 28842 citations. Previous affiliations of Steven A. Porcelli include Brigham and Women's Hospital & Yeshiva University.
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Journal ArticleDOI
An Antimicrobial Activity of Cytolytic T Cells Mediated by Granulysin
Steffen Stenger,Dennis A. Hanson,Rachel Teitelbaum,Puneet Dewan,Kayvan Niazi,Christopher J. Froelich,Tomas Ganz,Sybille Thoma-Uszynski,Agustı́n Melián,Christian Bogdan,Steven A. Porcelli,Barry R. Bloom,Alan M. Krensky,Robert L. Modlin +13 more
TL;DR: The ability of CTLs to kill intracellular M. tuberculosis was dependent on the presence of granulysin in cytotoxic granules, defining a mechanism by which T cells directly contribute to immunity against intrACEllular pathogens.
Journal ArticleDOI
Recognition of a lipid antigen by CD1-restricted αβ+ T cells
Evan M. Beckman,Steven A. Porcelli,Craig T. Morita,Samuel M. Behar,Stephen T. Furlong,Michael B. Brenner +5 more
TL;DR: In this paper, a purified CD1b-restricted antigen of Mycobacterium tuberculosis presented to alpha beta TCR+ T cells is mycolic acid, a family of alpha-branched, beta-hydroxy, long-chain fatty acids found in mycobacteria.
Journal ArticleDOI
CD1-restricted T cell recognition of microbial lipoglycan antigens.
Peter A. Sieling,Delphi Chatterjee,Steven A. Porcelli,Theodore I. Prigozy,Richard J. Mazzaccaro,T. Soriano,Barry R. Bloom,Michael B. Brenner,Mitchell Kronenberg,Patrick J. Brennan,Robert L. Modlin +10 more
TL;DR: It is shown here that human CD1b presents the defined mycobacterial lipoglycan lipoarabinomannan (LAM) to alpha beta T cell receptor-bearing lymphocytes, which resulted in T cells activated by LAM producing interferon gamma and were cytolytic.
Journal ArticleDOI
The CD1 system: antigen-presenting molecules for T cell recognition of lipids and glycolipids.
TL;DR: Structural, biochemical, and biophysical studies support the view that CD1 proteins bind the hydrophobic alkyl portions of these antigens directly and position the polar or hydrophilic head groups of bound lipids and glycolipids for highly specific interactions with T cell antigen receptors.
Journal ArticleDOI
Analysis of T cell antigen receptor (TCR) expression by human peripheral blood CD4-8- alpha/beta T cells demonstrates preferential use of several V beta genes and an invariant TCR alpha chain.
TL;DR: The expression of particular TCRs by DN alpha/beta T cells from multiple donors indicates that these cells, or at least a subpopulation of cells with this phenotype, recognize a limited spectrum of antigens and suggests that they may use nonpolymorphic antigen-presenting molecules.