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Sarah A. Sullivan
Researcher at Duke University
Publications - 9
Citations - 1663
Sarah A. Sullivan is an academic researcher from Duke University. The author has contributed to research in topics: T cell & Cytotoxic T cell. The author has an hindex of 6, co-authored 8 publications receiving 1410 citations.
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Journal ArticleDOI
Cutting Edge: Distinct Glycolytic and Lipid Oxidative Metabolic Programs Are Essential for Effector and Regulatory CD4+ T Cell Subsets
Ryan D. Michalek,Valerie A. Gerriets,Sarah R. Jacobs,Andrew N. Macintyre,Nancie J. MacIver,Emily F. Mason,Sarah A. Sullivan,Amanda G. Nichols,Jeffrey C. Rathmell +8 more
TL;DR: Teff and Treg were selectively increased in Glut1 transgenic mice and reliant on glucose metabolism, whereas Treg had activated AMP-activated protein kinase and were dependent on lipid oxidation.
Journal ArticleDOI
Differential Requirement of RasGRP1 for γδ T Cell Development and Activation
Yong Chen,Yong Chen,Xinxin Ci,Xinxin Ci,Balachandra K. Gorentla,Sarah A. Sullivan,James C. Stone,Weiguo Zhang,Pablo Pereira,Jianxin Lu,Xiao-Ping Zhong +10 more
TL;DR: It is demonstrated that RasGRP1 is critical for TCR-induced Erk1/2 activation in γδT cells, but it exerts different roles for γ ΔT cell generation and activation, and plays differential roles for αβ T cell development and production of IL-17.
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Regulation of RasGRP1 function in T cell development and activation by its unique tail domain.
Deirdre M. Fuller,Minghua Zhu,Xiaohua Song,Chih-wen Ou-Yang,Sarah A. Sullivan,James C. Stone,Weiguo Zhang +6 more
TL;DR: The physiological relevance of the tail domain in RasGRP1 function and control of Erk signaling is revealed and the deletion of this domain led to enhanced CD4+ T cell expansion in aged mice, as well as the production of autoantibodies.
Journal ArticleDOI
Role of LAT in the granule-mediated cytotoxicity of CD8 T cells.
Chih-wen Ou-Yang,Minghua Zhu,Deirdre M. Fuller,Sarah A. Sullivan,Mariana I. Chuck,Sarah C. Ogden,Qi-Jing Li,Weiguo Zhang +7 more
TL;DR: It is shown here that LAT-deficient CTLs failed to upregulate FasL and produce gamma interferon after engagement with target cells and had impaired granule-mediated killing and the data demonstrated that Lat-mediated signaling intricately regulates CTL cytotoxicity at multiple steps.
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A tale of two TRAPs: LAT and LAB in the regulation of lymphocyte development, activation, and autoimmunity
TL;DR: Recent advances on the function of LAT and LAB in the regulation of development and activation of immune cells are reviewed.