X
Xiao-Ping Zhong
Researcher at Duke University
Publications - 99
Citations - 4506
Xiao-Ping Zhong is an academic researcher from Duke University. The author has contributed to research in topics: T cell & Diacylglycerol kinase. The author has an hindex of 38, co-authored 99 publications receiving 4009 citations. Previous affiliations of Xiao-Ping Zhong include Wenzhou Medical College & Durham University.
Papers
More filters
Journal ArticleDOI
Clinical efficacy and immune regulation with peanut oral immunotherapy.
Stacie M. Jones,Laurent Pons,Joseph L. Roberts,Amy M. Scurlock,Tamara T. Perry,Mike Kulis,Wayne G. Shreffler,Pamela H. Steele,Karen A. Henry,Margaret Adair,James M. Francis,Stephen R. Durham,Brian P. Vickery,Xiao-Ping Zhong,A. Wesley Burks +14 more
TL;DR: Microarray data suggest a novel role for apoptosis in OIT, which induces clinical desensitization to peanut, with significant longer-term humoral and cellular changes.
Journal ArticleDOI
Disruption of diacylglycerol metabolism impairs the induction of T cell anergy
Benjamin A. Olenchock,Rishu Guo,Jeffery H. Carpenter,Martha S. Jordan,Matthew K. Topham,Gary A. Koretzky,Xiao-Ping Zhong +6 more
TL;DR: Regulation of diacylglycerol metabolism is critical in determining whether activation or anergy ensues after T cell receptor stimulation, and in vivo anergy induction was impaired in DGK-α-deficient mice.
Journal ArticleDOI
Enhanced T cell responses due to diacylglycerol kinase ζ deficiency
Xiao-Ping Zhong,Ehmonie A. Hainey,Benjamin A. Olenchock,Martha S. Jordan,Jonathan S. Maltzman,Kim E. Nichols,Hao Shen,Gary A. Koretzky +7 more
TL;DR: It is shown that DGKζ-deficient T cells are hyperresponsive to TCR stimulation both ex vivo and in vivo, and these results demonstrate the importance of DGK ζ as a physiological negative regulator of TCR signaling and T cell activation.
Journal ArticleDOI
The Role of Diacylglycerol Kinase ζ and Phosphatidic Acid in the Mechanical Activation of Mammalian Target of Rapamycin (mTOR) Signaling and Skeletal Muscle Hypertrophy
Jae-Sung You,Hannah C. Lincoln,Chan-Ran Kim,John Frey,Craig A. Goodman,Xiao-Ping Zhong,Troy A. Hornberger +6 more
TL;DR: PA synthesized by DGKζ regulates the mechanical activation of mTOR signaling and hypertrophy and could be a fundamental component of the mechanism(s) through which mechanical stimuli regulate skeletal muscle mass.
Journal ArticleDOI
Critical roles of mTOR Complex 1 and 2 for T follicular helper cell differentiation and germinal center responses.
Jialong Yang,Xingguang Lin,Yun Pan,Jinli Wang,Pengcheng Chen,Hongxiang Huang,Hai-Hui Xue,Jimin Gao,Xiao-Ping Zhong +8 more
TL;DR: It is reported here that mTOR in CD4 T cells is essential for Tfh differentiation and in Mtorf/f-Cd4Cre mice, both constitutive and inducible T fh differentiation is severely impaired, leading to defective germinal center B cell formation and antibody production.