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Sarah N. Hilmer
Researcher at Royal North Shore Hospital
Publications - 357
Citations - 15058
Sarah N. Hilmer is an academic researcher from Royal North Shore Hospital. The author has contributed to research in topics: Deprescribing & Polypharmacy. The author has an hindex of 56, co-authored 315 publications receiving 12170 citations. Previous affiliations of Sarah N. Hilmer include National Health and Medical Research Council & Concord Repatriation General Hospital.
Papers
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Journal ArticleDOI
Reducing Inappropriate Polypharmacy: The Process of Deprescribing
Ian A Scott,Ian A Scott,Sarah N. Hilmer,Sarah N. Hilmer,Emily Reeve,Emily Reeve,Kathleen N. Potter,David G. Le Couteur,Debbie Rigby,Debbie Rigby,Danijela Gnjidic,Chris Del Mar,Elizabeth E. Roughead,Amy Page,Jesse Jansen,Jennifer H. Martin +15 more
TL;DR: A deprescribing protocol is proposed comprising 5 steps: ascertain all drugs the patient is currently taking and the reasons for each one, and prioritize drugs for discontinuation that have the lowest benefit-harm ratio and lowest likelihood of adverse withdrawal reactions or disease rebound syndromes.
Journal ArticleDOI
Polypharmacy cutoff and outcomes: five or more medicines were used to identify community-dwelling older men at risk of different adverse outcomes.
Danijela Gnjidic,Sarah N. Hilmer,Sarah N. Hilmer,Fiona M. Blyth,Fiona M. Blyth,Vasi Naganathan,Vasi Naganathan,Louise M. Waite,Louise M. Waite,Markus J. Seibel,Markus J. Seibel,Andrew J. McLachlan,Andrew J. McLachlan,Robert G. Cumming,Robert G. Cumming,David J. Handelsman,David J. Handelsman,David G. Le Couteur,David G. Le Couteur +18 more
TL;DR: The study supports the use of five or more medications in the current definition of polypharmacy to estimate the medication-related adverse effects for frailty, disability, mortality, and falls.
Journal ArticleDOI
Calorie restriction induces mitochondrial biogenesis and bioenergetic efficiency.
Guillermo López-Lluch,Nicole D. Hunt,Bruce Jones,Min Zhu,Hamish A. Jamieson,Sarah N. Hilmer,María V. Cascajo,Joanne S. Allard,Donald K. Ingram,Plácido Navas,R. de Cabo +10 more
TL;DR: Calorie restriction can induce a peroxisome proliferation-activated receptor coactivator 1 alpha-dependent increase in mitochondria capable of efficient and balanced bioenergetics to reduce oxidative stress and attenuate age-dependent endogenous oxidative damage.
Journal ArticleDOI
A Drug Burden Index to Define the Functional Burden of Medications in Older People
Sarah N. Hilmer,Donald E. Mager,Donald E. Mager,Eleanor M. Simonsick,Ying Cao,S.M. Ling,B. Gwen Windham,Tamara B. Harris,Joseph T. Hanlon,Susan M. Rubin,Ronald I. Shorr,Douglas C. Bauer,Darrell R. Abernethy +12 more
TL;DR: The drug burden index demonstrates that anticholinergic and sedative drug exposure is associated with poorer function in community-dwelling older people and provides a useful evidence-based tool for assessing the functional effect of exposure to medications in this population.
Journal ArticleDOI
A systematic review of the emerging definition of ‘deprescribing’ with network analysis: implications for future research and clinical practice.
TL;DR: Findings show that there is lack of consensus on the definition of deprescribing and the following definition is proposed: 'Depresc prescribing is the process of withdrawal of an inappropriate medication, supervised by a health care professional with the goal of managing polypharmacy and improving outcomes'.