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David G. Le Couteur
Researcher at University of Sydney
Publications - 396
Citations - 24460
David G. Le Couteur is an academic researcher from University of Sydney. The author has contributed to research in topics: Population & Medicine. The author has an hindex of 66, co-authored 373 publications receiving 20810 citations. Previous affiliations of David G. Le Couteur include Prince of Wales Medical Research Institute & Princess Alexandra Hospital.
Papers
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Journal ArticleDOI
Resveratrol improves health and survival of mice on a high-calorie diet
Joseph A. Baur,Kevin J. Pearson,Nathaniel O Price,Hamish A. Jamieson,Carles Lerin,Avash Kalra,Vinayakumar Prabhu,Joanne S. Allard,Guillermo López-Lluch,Kaitlyn N. Lewis,Paul J. Pistell,Suresh Poosala,Kevin G. Becker,Olivier Boss,Dana M. Gwinn,Mingyi Wang,Sharan Ramaswamy,Kenneth W. Fishbein,Richard G. Spencer,Edward G. Lakatta,David G. Le Couteur,Reuben J. Shaw,Plácido Navas,Pere Puigserver,Donald K. Ingram,Rafael de Cabo,David A. Sinclair +26 more
TL;DR: It is shown that resveratrol shifts the physiology of middle-aged mice on a high-calorie diet towards that of mice onA standard diet and significantly increases their survival and point to new approaches for treating obesity-related disorders and diseases of ageing.
Journal ArticleDOI
Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span.
Kevin J. Pearson,Joseph A. Baur,Kaitlyn N. Lewis,Leonid Peshkin,Nathan L. Price,Nathan L. Price,Nazar Labinskyy,William R. Swindell,Davida Kamara,Robin K. Minor,Evelyn Perez,Hamish A. Jamieson,Yongqing Zhang,Stephen R. Dunn,Kumar Sharma,Nancy Pleshko,Laura A. Woollett,Anna Csiszar,Yuji Ikeno,David G. Le Couteur,Peter J. Elliott,Kevin G. Becker,Plácido Navas,Donald K. Ingram,Norman S. Wolf,Zoltan Ungvari,David A. Sinclair,Rafael de Cabo +27 more
TL;DR: It is found that resveratrol treatment has a range of beneficial effects in mice but does not increase the longevity of ad libitum-fed animals when started midlife.
Journal ArticleDOI
Reducing Inappropriate Polypharmacy: The Process of Deprescribing
Ian A Scott,Ian A Scott,Sarah N. Hilmer,Sarah N. Hilmer,Emily Reeve,Emily Reeve,Kathleen N. Potter,David G. Le Couteur,Debbie Rigby,Debbie Rigby,Danijela Gnjidic,Chris Del Mar,Elizabeth E. Roughead,Amy Page,Jesse Jansen,Jennifer H. Martin +15 more
TL;DR: A deprescribing protocol is proposed comprising 5 steps: ascertain all drugs the patient is currently taking and the reasons for each one, and prioritize drugs for discontinuation that have the lowest benefit-harm ratio and lowest likelihood of adverse withdrawal reactions or disease rebound syndromes.
Journal ArticleDOI
Polypharmacy cutoff and outcomes: five or more medicines were used to identify community-dwelling older men at risk of different adverse outcomes.
Danijela Gnjidic,Sarah N. Hilmer,Sarah N. Hilmer,Fiona M. Blyth,Fiona M. Blyth,Vasi Naganathan,Vasi Naganathan,Louise M. Waite,Louise M. Waite,Markus J. Seibel,Markus J. Seibel,Andrew J. McLachlan,Andrew J. McLachlan,Robert G. Cumming,Robert G. Cumming,David J. Handelsman,David J. Handelsman,David G. Le Couteur,David G. Le Couteur +18 more
TL;DR: The study supports the use of five or more medications in the current definition of polypharmacy to estimate the medication-related adverse effects for frailty, disability, mortality, and falls.
Journal ArticleDOI
The Ratio of Macronutrients, Not Caloric Intake, Dictates Cardiometabolic Health, Aging, and Longevity in Ad Libitum-Fed Mice.
Samantha M. Solon-Biet,Aisling C. McMahon,J. William O. Ballard,Kari Ruohonen,Lindsay E. Wu,Victoria C. Cogger,Alessandra Warren,Xin Huang,Nicolas Pichaud,Richard G. Melvin,Rahul Gokarn,Mamdouh Khalil,Nigel Turner,Gregory J. Cooney,David A. Sinclair,David A. Sinclair,David Raubenheimer,David G. Le Couteur,Stephen J. Simpson +18 more
TL;DR: The Geometric Framework, a state-space nutritional modeling method, was used to measure interactive effects of dietary energy, protein, fat, and carbohydrate on food intake, cardiometabolic phenotype, and longevity in mice fed one of 25 diets ad libitum, suggesting that longevity can be extended in ad Libitum-fed animals by manipulating the ratio of macronutrients.