S
Sascha Flohé
Researcher at University of Düsseldorf
Publications - 94
Citations - 2734
Sascha Flohé is an academic researcher from University of Düsseldorf. The author has contributed to research in topics: Cytokine & Sepsis. The author has an hindex of 27, co-authored 92 publications receiving 2519 citations. Previous affiliations of Sascha Flohé include University of Duisburg-Essen.
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Journal ArticleDOI
Induced Hypothermia Does Not Harm Hemodynamics after Polytrauma: A Porcine Model
Matthias Weuster,Philipp Mommsen,Roman Pfeifer,Juliane Mohr,Juliane Mohr,Steffen Ruchholtz,Sascha Flohé,Matthias Fröhlich,Claudia Keibl,Andreas Seekamp,Martijn van Griensven,Martijn van Griensven,Ingo Witte +12 more
TL;DR: Therapeutic hypothermia revealed hints for tissue protective impact and might be a useful tool for intensive care after polytrauma, but the chosen length for therapeutichypothermia was too short.
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Human heat shock protein 60 induces maturation of dendritic cells versus a Th1-promoting phenotype.
Stefanie B. Flohé,Jutta Brüggemann,Sven Lendemans,Marina Nikulina,Guido Meierhoff,Sascha Flohé,Hubert Kolb +6 more
TL;DR: HSP60 was found to rapidly activate the mitogen-activated protein kinases p38, c-Jun N-terminal kinase, and extracellular signal-regulated kinase as well as IκB in DC and stimulates DC more rapidly than LPS and elicits a Th1-promoting phenotype.
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Depletion of neutrophil extracellular traps in vivo results in hypersusceptibility to polymicrobial sepsis in mice.
Wei Meng,Adnana Paunel-Görgülü,Sascha Flohé,Almuth Hoffmann,Ingo Witte,Colin R. MacKenzie,Stephan E Baldus,Joachim Windolf,Tim Lögters +8 more
TL;DR: This study shows, for the first time, that depletion of NETs by rhDNase administration impedes the early immune response and aggravates the pathology that follows polymicrobial sepsis in vivo.
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Dendritic cells during polymicrobial sepsis rapidly mature but fail to initiate a protective Th1-type immune response
Stefanie B. Flohé,Hemant Agrawal,Daniel Schmitz,Michaela Gertz,Sascha Flohé,F. Ulrich Schade +5 more
TL;DR: During sepsis, splenic DC acquire a state of aberrant responsiveness to bacterial stimuli, and two DC subtypes are selectively lost, which might contribute to impaired host response against bacteria during sepsi.
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Antigen-pulsed epidermal Langerhans cells protect susceptible mice from infection with the intracellular parasite Leishmania major
TL;DR: It is demonstrated that Epidermal Langerhans cells are able to serve as a natural adjuvant and to induce a protective immune response to L. major infection based on the initiation of a Th1‐like response that is likely to be mediated by IL‐12.