Hydrogels for biomedical applications.

The study of nanostructured drug delivery systems allows the development of novel platforms for the efficient transport and controlled release of drug molecules in the harsh microenvironment of diseased tissues of living systems, thus offering a wide range of functional nanoplatforms for smart application in biotechnology and nanomedicine. This article highlights recent advances of smart nanocarriers composed of organic (including polymeric micelles and vesicles, liposomes, dendrimers, and hydrogels) and inorganic (including quantum dots, gold and mesoporous silica nanoparticles) materials. Despite the remarkable developments of recent synthetic methodologies, most of all nanocarriers’ action is associated with a number of unwanted side effects that diminish their efficient use in biotechnology and nanomedicine applications. This highlights some critical issues in the design and engineering of nanocarrier systems for biotechnology applications, arising from the complex environment and multiform interactions established within the specific biological media.

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Smart Nanoparticles for Drug Delivery Application: Development of Versatile Nanocarrier Platforms in Biotechnology and Nanomedicine

Solid lipid nanoparticles (SLNs) are nanocarriers developed as substitute colloidal drug delivery systems parallel to liposomes, lipid emulsions, polymeric nanoparticles, and so forth. Owing to their unique size dependent properties and ability to incorporate drugs, SLNs present an opportunity to build up new therapeutic prototypes for drug delivery and targeting. SLNs hold great potential for attaining the goal of targeted and controlled drug delivery, which currently draws the interest of researchers worldwide. The present review sheds light on different aspects of SLNs including fabrication and characterization techniques, formulation variables, routes of administration, surface modifications, toxicity, and biomedical applications.

Solid Lipid Nanoparticles: Emerging Colloidal Nano Drug Delivery Systems

Solid lipid nanoparticles and nanostructured lipid carriers: A review emphasizing on particle structure and drug release

The efficacy of current standard chemotherapy is suboptimal due to the poor solubility and short half-lives of chemotherapeutic agents, as well as their high toxicity and lack of specificity which may result in severe side effects, noncompliance and patient inconvenience. The application of nanotechnology has revolutionized the pharmaceutical industry and attracted increasing attention as a significant means for optimizing the delivery of chemotherapeutic agents and enhancing their efficiency and safety profiles. Nanostructured lipid carriers (NLCs) are lipid-based formulations that have been broadly studied as drug delivery systems. They have a solid matrix at room temperature and are considered superior to many other traditional lipid-based nanocarriers such as nanoemulsions, liposomes and solid lipid nanoparticles (SLNs) due to their enhanced physical stability, improved drug loading capacity, and biocompatibility. This review focuses on the latest advances in the use of NLCs as drug delivery systems and their preparation and characterization techniques with special emphasis on their applications as delivery systems for chemotherapeutic agents and different strategies for their use in tumor targeting.

Nanostructured Lipid Carriers for Delivery of Chemotherapeutics: A Review.

Nanostructured lipid carriers for site-specific drug delivery

Design and in vivo evaluation of solid lipid nanoparticulate systems of Olanzapine for acute phase schizophrenia treatment: Investigations on antipsychotic potential and adverse effects.

DoE based Olanzapine loaded poly-caprolactone nanoparticles decreases extrapyramidal effects in rodent model.

The present study describes the first fully validated RP-HPLC method for the quantification of temozolomide, an anti-cancer drug, in rat plasma. The method is simple, rapid, specific, sensitive and...

A simplified and sensitive validated RP-HPLC method for determination of temozolomide in rat plasma and its application to a pharmacokinetic study

Aims: To develop and validate two accurate and precise UV spectrophotometric methods for the estimation of widely prescribed anti psychotic drug-Olanzapine in bulk, formulations and preformulation studies.Methodology: Two different solvent systems optimized for the analysis (100 mM hydrochloric acid with pH 1.2 and phosphate buffer saline with pH 7.4), were based on various criteria such as applicability of the method, sensitivity, ease of sample preparation, cost effectiveness, stability of drug in investigating medium, and reproducibility. Olanzapine was estimated at 258 nm in 100 mM hydrochloric acid and 252 nm in phosphate buffer saline.Results: The linear regression equations obtained by applying least square regression analysis for Olanzapine were found to be: Absorbance = 0.0697 × concentration in µgml–1+ 0.008; r2= 0.9999) in 100 mM hydrochloric acid; absorbance = 0.0571 × concentration in µgml–1- 0.0052; r2 = 0.9998) in the phosphate buffer saline. Sandell’s sensitivity was found to be about 0.0144 µgcm−1 for hydrochloric acid and 0.0175 µgcm−1 for phosphate buffer saline. The apparent molar absorptivity was calculated to be 2.17x104mol−1cm−1 and 1.78x104 mol−1cm−1 in hydrochloric acid and phosphate buffer saline respectively.Conclusion: Two spectrophometric methods for the analysis of Olanzapine have been developed successfully and validated as per ICH guidelines. Developed methods were successfully applied for the determination of Olanzapine in commercial tablets of varying strengths and various preformulation parameters of the drug such as dissociation constant.

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Satish Reddi

Papers

Nanostructured lipid carriers for site-specific drug delivery

Design and in vivo evaluation of solid lipid nanoparticulate systems of Olanzapine for acute phase schizophrenia treatment: Investigations on antipsychotic potential and adverse effects.

DoE based Olanzapine loaded poly-caprolactone nanoparticles decreases extrapyramidal effects in rodent model.

A simplified and sensitive validated RP-HPLC method for determination of temozolomide in rat plasma and its application to a pharmacokinetic study

Validated UV Spectrophotometric Methods for the Estimation of Olanzapine in Bulk, Pharmaceutical Formulations and Preformulation Studies