Showing papers in "European Journal of Pharmaceutical Sciences in 2017"

TL;DR: In this paper, the authors define a new category which shades the frontier between drugs and food and define a nutraceutical as "a food or part of a food that provides benefits health in addition to its nutritional content".

TL;DR: The main focus of this review is applicability of drug/drug nanoparticle loaded nanofibers in the management of diseases/disorders related to the brain, eye, ear, cardiovascular system, lungs and oral cavity.

TL;DR: This review paper provides detailed suggestions as guidelines to materials and formulation scientists for designing biocompatible pH‐responsive materials with hydrazone linkages and identifying future studies.

TL;DR: The study shows that phospholipid‐based phytosome is a promising and viable strategy for improving the delivery of apigenin and similar phytoconstituents with low aqueous solubility.

TL;DR: The exosome yield was significantly different among the cell types, and all the exosomes evaluated in this study showed comparable physicochemical and pharmacokinetic properties.

TL;DR: Gellan /xanthan showed superiority over gellan/HPMC in all studied parameters and is considered as a promising mucoadhesive nanoemulsion‐based ion induced in situ gelling formula for topical administration of acetazolamide.

TL;DR: In this paper, a review of the latest challenging findings to provide novel and groundbreaking ideas for successful tumor early diagnosis and follow-up is presented, highlighting the latest challenges and breakthrough ideas.

TL;DR: The potent and selective EGFR/HER2 dual inhibitor, pyrotinib, displayed robust anti‐tumor effects on HER2‐overexpressing xenograft models and sufficiently safety windows in animals as well as favorable pharmacokinetic properties in human, which substantially ensures current clinical development.

TL;DR: In vitro dissolution tests verified that the gliadin nanofibers with a heterogeneous drug distribution could provide a better sustained release profile than its counterpart in terms of initial burst release and sustained release time period.

TL;DR: The developed liposomal carriers of psoralen were found to be promising and can find application for optimal safety and efficacy of topical PUVA in psoriasis.

TL;DR: Synthetic biomaterials that mimic blood cell and nanocrystallization of blood cells have been developed and may represent the future direction for blood cell membrane‐based delivery systems.

TL;DR: Urine and faeces were shown to be important routes of excretion, with urine as the primary route in both humans and animals, and metabolite profiles of semaglutide in humans appear to be similar to the profiles from the nonclinical species investigated.

TL;DR: Normal fat mass is a size descriptor based on allometric theory that partitions total body mass into fat free mass and fat mass and can be used to improve drug dosing.

TL;DR: How novel treatment individualization biomarkers can be identified using a clinical metabolomics-based approach is discussed, and how concepts inspired from the field of PK-PD modeling can be integrated in this process in order to increase the clinical relevance of identified biomarkers and precision medicine.

TL;DR: The fact that PVP/Cipro solutions in aqueous acetic acid can be used either to produce transparent soft films or nanofiber mats renders this process highly suitable for the fabrication of new‐generation potential dressings for wound management and care.

TL;DR: The role of EV in tissue repair is reviewed, summarising first their contribution to the regulation of immune cell function, and discussing the implications for the resolution of inflammation during repair.

TL;DR: Overall, the UA‐modified MSN prodrug delivery system can be a promising drug carrier for improving the bioavailability of UA, and further enhance its anti‐cancer efficacy.

TL;DR: In vitro deposition measurements have been conducted in a human‐based model of the upper airways, and several groups within MP1404 SimInhale have computed the same case using a variety of simulation and discretization approaches, and a critical discussion of the performance of the various simulation methods is provided.

TL;DR: Some of the most highly sought receptors to be targeted in selective cancer treatment are highlighted and some of the recent advances in cancer targeting using drug‐loaded ligand‐conjugated nanocarriers are reported.

TL;DR: The data suggest that the presence of ApoB in the 100,000 pellet is a clear marker for malignancy, and the specific composition of microRNAs (miRNAs) and proteins of extracellular vesicles (EVs) that urothelial tumour cells of bladder mucosa release into the urine, could reflect their pathologic condition.

TL;DR: In this paper, a review describes the essential physico-chemical properties of oral phospholipid excipients, the fate of orally administered phospholipsid with respect to absorption and metabolism in the GI tract, and the main dosage forms used for oral administration containing PHs.

TL;DR: The results demonstrated that the paeonol transethosomes had a narrow size distribution, high encapsulation efficiency, and long residence in the plasma, which remarkably enhanced the bioavailability of pae onol.

TL;DR: This review tries to understand why nasal powder formulations are still less common than liquid ones by analyzing whether this depends on the lack of real evidence of superior therapeutic benefit of powders, therapeutic and/or commercial interest, efficient manufacturing methods or availability of suitable and affordable delivery devices.

TL;DR: The present study concluded that glycerol is suitable plasticizer compared to others for manufacturing pullulan based oral films.

TL;DR: The complexity of the stomach with regard to anatomy, physiology and gastric fluid composition is emphasized and several of the processes to which a dosage form can be exposed during its passage through the stomach and the implications for gastrointestinal drug behaviour and systemic drug disposition are discussed.

TL;DR: The biocompatibility, less cytotoxicity and high aqueous dispersibility of as‐synthesized CQDs are motivated to design carbon quantum dot (CQD) tailored calcium alginate (CA) hydrogel films with an aim to controlled delivery of glycopeptides antibiotic vancomycin in the gastrointestinal tract (GI).

TL;DR: The successful verification of safety, efficacy and stability of microneedle patch advocated the suitability of the formulation for transdermal use and showed a comparable anti‐inflammatory activity in rats when compared to its existing approved marketed oral tablet.

TL;DR: Results show that several urinary exosomal proteins identified as prostate cancer biomarkers by mass spectrometry have a high diagnostic value also when analyzed by immunology‐based methods, thus bringing these biomarkers closer to a potential clinical use.

TL;DR: The study revealed successful formulation of SNEDDS for oral delivery of polypeptide‐k and the biochemical, hematological and histopathological results of streptozotocin induced diabetic rats shown promising antidiabetic potential of PPK loaded in SNED DS at its both the doses.

TL;DR: The novel results pave the way to utilize piperine‐PNL delivery system for other poorly soluble, highly metabolized compounds that currently cannot be administered orally.