S
Satoshi Baba
Researcher at Daiichi Sankyo
Publications - 19
Citations - 388
Satoshi Baba is an academic researcher from Daiichi Sankyo. The author has contributed to research in topics: Gene cluster & Gene. The author has an hindex of 10, co-authored 18 publications receiving 338 citations. Previous affiliations of Satoshi Baba include Osaka University & University of California, Berkeley.
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Journal ArticleDOI
COPII-coated membranes function as transport carriers of intracellular procollagen I.
TL;DR: This study demonstrates the existence of mobile COPII-coated vesicles that completely encapsulate the cargo PC1 and are physically separated from ER and develops a cell-free COPII vesicle budding reaction that reconstitutes the capture of PC1 into large COPIIVesicles.
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The biosynthesis of liposidomycin-like A-90289 antibiotics featuring a new type of sulfotransferase.
Masanori Funabashi,Satoshi Baba,Koichi Nonaka,Masahiko Hosobuchi,Yoko Fujita,Tomoyuki Shibata,Steven G. Van Lanen +6 more
TL;DR: During screening for new compounds that inhibit bacterial translocase I, a series of related compounds from Streptomyces sp.
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Characterization of LipL as a Non-heme, Fe(II)-dependent α-Ketoglutarate:UMP Dioxygenase That Generates Uridine-5′-aldehyde during A-90289 Biosynthesis
Zhaoyong Yang,Xiuling Chi,Masanori Funabashi,Satoshi Baba,Koichi Nonaka,Pallab Pahari,Jason M. Unrine,Jesse M. Jacobsen,Gregory I. Elliott,Jürgen Rohr,Steven G. Van Lanen +10 more
TL;DR: In vitro data is provided to support the functional assignment of LipL, the putative TauD enzyme from the A-90289 gene cluster, as a non-heme, Fe(II)-dependent α-KG:UMP dioxygenase that produces uridine-5′-aldehyde to initiate the biosynthesis of the modified uridine component of A- 90289.
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Identification and characterization of Penicillium citrinum VeA and LaeA as global regulators for ML-236B production.
TL;DR: Results indicated that VeA and LaeA dominantly control the biosynthesis of ML-236B, and the enhanced production in the strain S-1567 is attributable to the mutation in laeA.
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Structure‐Based Gene Targeting Discovery of Sphaerimicin, a Bacterial Translocase I Inhibitor
Masanori Funabashi,Satoshi Baba,Toshio Takatsu,Masaaki Kizuka,Yasuo Ohata,Masahiro Tanaka,Koichi Nonaka,Anatol P. Spork,Christian Ducho,Wei-Chen Leyla Chen,Steven G. Van Lanen +10 more
TL;DR: Using a gene-targeting approach aimed at identifying potential L-threonine:uridine-5'-transaldolases that catalyze the formation of (5'S,6'S)-C-glycyluridine, a new bacterial translocase I inhibitor was discovered from an actinomycete following fermentation optimization.