T
Takuya Nihira
Researcher at Mahidol University
Publications - 184
Citations - 5330
Takuya Nihira is an academic researcher from Mahidol University. The author has contributed to research in topics: Streptomyces & Virginiamycin. The author has an hindex of 40, co-authored 184 publications receiving 5024 citations. Previous affiliations of Takuya Nihira include Kitasato University & Toyama Prefectural University.
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A complex role for the γ‐butyrolactone SCB1 in regulating antibiotic production in Streptomyces coelicolor A3(2)
TL;DR: Results indicate a complex mechanism for γ‐butyrolactone‐mediated regulation of antibiotic biosynthesis in S. coelicolor, and indicate that scbR represses its own expression while activating that of scbA, and that ScbA is a positive autoregulator in addition to being required for €¬1,000,000 production.
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Polyketide synthase gene responsible for citrinin biosynthesis in Monascus purpureus.
TL;DR: Citrinin produced by Aspergillus, Penicillium, and Monascus species is a polyketide compound that has nephrotoxic activity in mammals and is bactericidal toward gram-positive bacteria, so knowledge of thecitrinin biosynthetic genes is needed so that citrinin-nonproducing strains can be generated.
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Virginiae Butanolide Binding Protein from Streptomyces virginiae EVIDENCE THAT VbrA IS NOT THE VIRGINIAE BUTANOLIDE BINDING PROTEIN AND REIDENTIFICATION OF THE TRUE BINDING PROTEIN
TL;DR: Okamoto et al. as mentioned in this paper reported the purification and molecular cloning of VbrA, a putative VB binding protein, by repurification by anion exchange, gel filtration, heparin, and hydrophobic interaction chromatography.
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A bacterial hormone (the SCB1) directly controls the expression of a pathway-specific regulatory gene in the cryptic type I polyketide biosynthetic gene cluster of Streptomyces coelicolor
Eriko Takano,Hiroshi Kinoshita,Vassilis Mersinias,Giselda Bucca,Graham Hotchkiss,Takuya Nihira,Colin P. Smith,Mervyn J. Bibb,Wolfgang Wohlleben,Keith F. Chater +9 more
TL;DR: This is the first report with comprehensive in vivo and in vitro data to show that a γ‐butyrolactone‐binding protein directly regulates a secondary metabolite pathway‐specific regulatory gene in Streptomyces.
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Purification and Structural Determination of SCB1, a γ-Butyrolactone That Elicits Antibiotic Production in Streptomyces coelicolor A3(2)
Eriko Takano,Takuya Nihira,Yoshitaka Hara,Jo J. Jones,Craig J.L. Gershater,Yasuhiro Yamada,Mervyn J. Bibb +6 more
TL;DR: Bioassays of chemically synthesized SCB1, and of its purified stereoisomers, suggest thatSCB1 acts in a highly specific manner to elicit the production of both actinorhodin and undecylprodigiosin, the two pigmented antibiotics made by S. coelicolor.