S
Satoshi Ikemoto
Researcher at National Institute on Drug Abuse
Publications - 72
Citations - 8390
Satoshi Ikemoto is an academic researcher from National Institute on Drug Abuse. The author has contributed to research in topics: Ventral tegmental area & Nucleus accumbens. The author has an hindex of 36, co-authored 65 publications receiving 7739 citations. Previous affiliations of Satoshi Ikemoto include United States Department of Health and Human Services & Bowling Green State University.
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Journal ArticleDOI
The role of nucleus accumbens dopamine in motivated behavior: a unifying interpretation with special reference to reward-seeking
Satoshi Ikemoto,Jaak Panksepp +1 more
TL;DR: The present analysis suggests that NAS DA plays an important role in sensorimotor integrations that facilitate flexible approach responses, and offers the following interpretation for the finding that both conditioned and unconditioned aversive stimuli stimulate DA release in the NAS: NAS DA invigorates approach responses toward 'safety'.
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Dopamine reward circuitry: two projection systems from the ventral midbrain to the nucleus accumbens-olfactory tubercle complex.
TL;DR: Experiments suggest that dopaminergic neurons localized in the posteromedial ventral tegmental area (VTA) and central linear nucleus raphe selectively project to the ventromedial striatum (medial olfactory tubercle and medial nucleus accumbens shell), whereas the anteromedial VTA has few if any projections to the vents of the ventral striatum.
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Localization of brain reinforcement mechanisms: intracranial self-administration and intracranial place-conditioning studies.
TL;DR: Overall, the ICSA and ICPC studies indicate that there are a number of receptors, neuronal pathways, and discrete CNS sites involved in brain reward mechanisms.
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Brain reward circuitry beyond the mesolimbic dopamine system: a neurobiological theory.
TL;DR: A neurobiological theory claiming that there is an intrinsic central process that coordinates various selective functions (including perceptual, visceral, and reinforcement processes) into a global function of approach is outlined.
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Role of Dopamine D1 and D2 Receptors in the Nucleus Accumbens in Mediating Reward
TL;DR: The present results suggest that concurrent activation of D1- and D2-type receptors in the shell of the ACB had a cooperative effect on DA-mediated reward processes.