A.L.-P. thanks CSIC for a contract under the JAE-doctor
program. Financial support by PLE2009 project from MCIINN
and Consolider-Ingenio 2010 (proyecto MULTICAT) are also
acknowledged.

Gold-catalyzed carbon-heteroatom bond-forming reactions.

2.4. Tandem sp-sp Coupling/Cyclization 3418 3. Cycloaddition Reactions 3418 3.1. [3+2] Cycloaddition 3418 3.1.1. Triazole/Isoxazole-Forming Reactions 3418 3.1.2. Reactions of Azomethine Ylides 3419 3.1.3. Cycloaddition of Nitrones 3422 3.1.4. Other [3+2] Reaction 3422 3.2. [4+2] Heterocycloaddition 3422 3.3. [2+2] Cycloaddition 3424 4. Cycloisomerization of Enynes/Diynes 3425 5. Intramolecular Friedel-Crafts-Type Reactions 3428 6. Reactions of R-Diazocarbonyl Compounds 3429 7. Aziridination of Olefins 3431 8. N/O-Vinylation/Arylation 3431 9. Radical Cyclization of Haloalkenes and Haloalkynes 3433

Coinage Metal-Assisted Synthesis of Heterocycles

Synthesis of Heterocycles via Palladium-Catalyzed Carbonylations

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Chemicals from Alkynes with Palladium Catalysts

Transition Metal Catalyzed Cycloisomerizations of 1,n-Allenynes and -Allenenes

A facile access to spiro furanone skeleton based on Pd(II)-mediated cyclization–carbonylation of propargylic esters

Die direkte Umwandlung einer terminalen Alkinfunktion in einen β-Methoxyacrylat-Rest gelingt mithilfe eines Bisoxazolin(box)-Liganden. Acetyl- und Ketal-Schutzgruppen werden unter den Reaktionsbedingungen ebenso wenig angegriffen wie freie Hydroxygruppen und saureempfindliche glycosidische Bindungen. (±)-Dihydrokawain wurde aus dem Homopropargylalkohol in einem Eintopfverfahren synthetisiert. tfa=Trifluoracetat.

Intermolecular methoxycarbonylation of terminal alkynes catalyzed by palladium(II) bis(oxazoline) complexes.

Bis(oxazoline)-palladium(II) catalyzed carbonylation of homopropargyl alcohols afforded acyclic methoxyacrylate 2 and 6-membered lactone 3a, 3b, 3d, 3e, 3f, 3g, 3h, 3i, 3j, 3k in good combined yield. In the case of propargyl alcohols, 5-membered lactones 3p, 3q, 16 were obtained in moderate yields. The one-pot synthesis of kawa lactones 3a, 3r, 3s and formal synthesis of dihydroxycystothiazole A and dihydroxycystothiazole C are presented. To elucidate the stereochemistry of (+)-annularin G and (−)-annularin H, the first asymmetric syntheses of these natural products were achieved.

Satoshi Motodate

Papers

A facile access to spiro furanone skeleton based on Pd(II)-mediated cyclization–carbonylation of propargylic esters

Intermolecular methoxycarbonylation of terminal alkynes catalyzed by palladium(II) bis(oxazoline) complexes.

Synthesis of β‐Methoxyacrylate Natural Products Based on Box‐PdII‐Catalyzed Intermolecular Methoxycarbonylation of Alkynoles

meso-Phbox-Pd(II) catalyzed tandem carbonylative cyclization of 1-ethynyl-1-propargyl acetate.

Parallel kinetic resolution of propargyl ketols: formal synthesis of (+)-bakkenolide A