Sattanathan Paramasivan

TL;DR: In this article four case studies are presented to indicate the strengths and limitations of CD in investigations of the properties of quadruplex structures formed by telomere repeat sequences.

TL;DR: A mix and measure fluorescent screening method has been developed, that utilizes multiple reporter molecules that bind to different features of quadruplex DNA that have the potential to form quadruplex structures.

TL;DR: In this article, the authors optimized the release of active telmisartan in fibrotic liver to be depot-like (that is, a constant therapeutic concentration) through the molecular design of brush-arm star polymers, and showed that these lead to improved efficacy and to the avoidance of dose-limiting hypotension in both metabolically and chemically induced mouse models of hepatic fibrosis.

TL;DR: In this article, a macromolecular prodrug platform for predictive prodrug design was proposed, using bromodomain and extra-terminal (BET) protein inhibitors.

TL;DR: Macromolecular telmisartan prodrugs optimized for preferential release in fibrotic liver tissue reduce liver fibrosis in mouse models, and are retained and well tolerated in the liver tissue of rats and dogs.