S
Sawa Kostin
Researcher at Max Planck Society
Publications - 142
Citations - 14920
Sawa Kostin is an academic researcher from Max Planck Society. The author has contributed to research in topics: Myocyte & Apoptosis. The author has an hindex of 60, co-authored 142 publications receiving 13812 citations. Previous affiliations of Sawa Kostin include University of Göttingen & University of Hawaii at Manoa.
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Journal ArticleDOI
Progression From Compensated Hypertrophy to Failure in the Pressure-Overloaded Human Heart Structural Deterioration and Compensatory Mechanisms
Stefan Hein,Eyal Arnon,Sawa Kostin,Markus Schönburg,Albrecht Elsässer,V. Polyakova,Erwin P. Bauer,Wolf-Peter Klövekorn,Jutta Schaper +8 more
TL;DR: These structure-function correlations confirm the hypothesis that transition to HF occurs by fibrosis and myocyte degeneration partially compensated by hypertrophy involving DNA synthesis and transcription.
Journal ArticleDOI
Tissue Engineering of a Differentiated Cardiac Muscle Construct
Wolfram-Hubertus Zimmermann,Karin Schneiderbanger,Pia Schubert,Michael Didié,Felix Münzel,Jürgen F. Heubach,Sawa Kostin,Winfried Neuhuber,Thomas Eschenhagen +8 more
TL;DR: It is demonstrated that cardiac myocytes from neonatal rats, when mixed with collagen I and matrix factors, cast in circular molds, and subjected to phasic mechanical stretch, reconstitute ring-shaped EHTs that display important hallmarks of differentiated myocardium.
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Acquisition of the contractile phenotype by murine arterial smooth muscle cells depends on the Mir143/145 gene cluster
Thomas Boettger,Nadine Beetz,Sawa Kostin,Johanna Schneider,Marcus Krüger,Lutz Hein,Thomas Braun +6 more
TL;DR: It is demonstrated that the mouse miR-143/145 cluster, expression of which is confined to SMCs during development, is required for VSMC acquisition of the contractile phenotype and manipulated expression may offer a new approach for influencing vascular repair and attenuating arteriosclerosis pathogenesis.
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Bone Marrow-Derived Cells Do Not Incorporate Into the Adult Growing Vasculature
Tibor Ziegelhoeffer,Borja Fernandez,Sawa Kostin,Matthias Heil,Robert Voswinckel,Armin Helisch,Wolfgang Schaper +6 more
TL;DR: The findings suggest that in the adult organism, bone marrow-Derived cells do not promote vascular growth by incorporating into vessel walls but may function as supporting cells.
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Sirt7 Increases Stress Resistance of Cardiomyocytes and Prevents Apoptosis and Inflammatory Cardiomyopathy in Mice
Olesya Vakhrusheva,Christian Smolka,Praveen Gajawada,Sawa Kostin,Thomas Boettger,Thomas Kubin,Thomas Braun,Eva Bober +7 more
TL;DR: It is proposed that enhanced activation of p53 by lack of Sirt7-mediated deacetylation contributes to the heart phenotype of SIRT7 mutant mice, suggesting a critical role of Sirts in the regulation of stress responses and cell death in the heart.