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Wolfgang Schaper
Researcher at Max Planck Society
Publications - 439
Citations - 28024
Wolfgang Schaper is an academic researcher from Max Planck Society. The author has contributed to research in topics: Arteriogenesis & Collateral circulation. The author has an hindex of 86, co-authored 433 publications receiving 27224 citations. Previous affiliations of Wolfgang Schaper include University of Giessen & University of Antwerp.
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Journal ArticleDOI
Synergism between vascular endothelial growth factor and placental growth factor contributes to angiogenesis and plasma extravasation in pathological conditions
Peter Carmeliet,Lieve Moons,Aernout Luttun,Valeria Vincenti,Veerle Compernolle,Maria De Mol,Yan Wu,Françoise Bono,Laetitia Devy,Heike Beck,Dimitri Scholz,Till Acker,Tina DiPalma,Mieke Dewerchin,Agnès Noël,Ingeborg Stalmans,Adriano Barra,S. Blacher,Thierry VandenDriessche,Annica Pontén,Ulf Eriksson,Karl H. Plate,Jean-Michel Foidart,Wolfgang Schaper,D. Stephen Charnock-Jones,Daniel J. Hicklin,Jean-Marc Herbert,Desire Collen,M. Graziella Persico +28 more
TL;DR: It is reported that embryonic angiogenesis in mice was not affected by deficiency of PlGF, andTransplantation of wild-type bone marrow rescued the impairedAngiogenesis and collateral growth in Pgf−/− mice, indicating that PlGF might have contributed to vessel growth in the adult by mobilizing bone-marrow–derived cells.
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The Cardiac Mechanical Stretch Sensor Machinery Involves a Z Disc Complex that Is Defective in a Subset of Human Dilated Cardiomyopathy
Ralph Knöll,Masahiko Hoshijima,Hal M. Hoffman,Veronika Person,Ilka Lorenzen-Schmidt,Marie Louise Bang,Takeharu Hayashi,Nobuyuki Shiga,Hideo Yasukawa,Wolfgang Schaper,William J. McKenna,Mitsuhiro Yokoyama,Nicholas J. Schork,Jeffrey H. Omens,Andrew D. McCulloch,Akinori Kimura,Carol C. Gregorio,Wolfgang Poller,Jutta Schaper,Heinz P. Schultheiss,Kenneth R. Chien +20 more
TL;DR: It is proposed that a Z disc MLP/T-cap complex is a key component of the in vivo cardiomyocyte stretch sensor machinery, and that defects in the complex can lead to human DCM and associated heart failure.
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Monocyte activation in angiogenesis and collateral growth in the rabbit hindlimb.
TL;DR: The results indicate that monocyte activation plays a major role in angiogenesis and collateral artery growth in rabbits after femoral artery occlusion.
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Bone Marrow-Derived Cells Do Not Incorporate Into the Adult Growing Vasculature
Tibor Ziegelhoeffer,Borja Fernandez,Sawa Kostin,Matthias Heil,Robert Voswinckel,Armin Helisch,Wolfgang Schaper +6 more
TL;DR: The findings suggest that in the adult organism, bone marrow-Derived cells do not promote vascular growth by incorporating into vessel walls but may function as supporting cells.
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Ischemic preconditioning reduces infarct size in swine myocardium.
TL;DR: It is concluded that stunning swineMyocardium with two cycles of a 10-minute LAD occlusion followed by reperfusion increases ischemic tolerance but that changes in regional demand in stunned myocardium do not predict the marked reduction in infarct size that follows a subsequent 60-minute period of ischemia.