Summary Type 1 diabetes is a chronic autoimmune disease characterised by insulin deficiency and resultant hyperglycaemia. Knowledge of type 1 diabetes has rapidly increased over the past 25 years, resulting in a broad understanding about many aspects of the disease, including its genetics, epidemiology, immune and β-cell phenotypes, and disease burden. Interventions to preserve β cells have been tested, and several methods to improve clinical disease management have been assessed. However, wide gaps still exist in our understanding of type 1 diabetes and our ability to standardise clinical care and decrease disease-associated complications and burden. This Seminar gives an overview of the current understanding of the disease and potential future directions for research and care.

Type 1 diabetes

Science and technologies based on terahertz frequency electromagnetic radiation (100 GHz–30 THz) have developed rapidly over the last 30 years. For most of the 20th Century, terahertz radiation, then referred to as sub-millimeter wave or far-infrared radiation, was mainly utilized by astronomers and some spectroscopists. Following the development of laser based terahertz time-domain spectroscopy in the 1980s and 1990s the field of THz science and technology expanded rapidly, to the extent that it now touches many areas from fundamental science to 'real world' applications. For example THz radiation is being used to optimize materials for new solar cells, and may also be a key technology for the next generation of airport security scanners. While the field was emerging it was possible to keep track of all new developments, however now the field has grown so much that it is increasingly difficult to follow the diverse range of new discoveries and applications that are appearing. At this point in time, when the field of THz science and technology is moving from an emerging to a more established and interdisciplinary field, it is apt to present a roadmap to help identify the breadth and future directions of the field. The aim of this roadmap is to present a snapshot of the present state of THz science and technology in 2017, and provide an opinion on the challenges and opportunities that the future holds. To be able to achieve this aim, we have invited a group of international experts to write 18 sections that cover most of the key areas of THz science and technology. We hope that The 2017 Roadmap on THz science and technology will prove to be a useful resource by providing a wide ranging introduction to the capabilities of THz radiation for those outside or just entering the field as well as providing perspective and breadth for those who are well established. We also feel that this review should serve as a useful guide for government and funding agencies.

The 2016 terahertz science and technology roadmap

A topical review of numerical and experimental studies of supercontinuum generation in photonic crystal fiber is presented over the full range of experimentally reported parameters, from the femtosecond to the continuous-wave regime. Results from numerical simulations are used to discuss the temporal and spectral characteristics of the supercontinuum, and to interpret the physics of the underlying spectral broadening processes. Particular attention is given to the case of supercontinuum generation seeded by femtosecond pulses in the anomalous group velocity dispersion regime of photonic crystal fiber, where the processes of soliton fission, stimulated Raman scattering, and dispersive wave generation are reviewed in detail. The corresponding intensity and phase stability properties of the supercontinuum spectra generated under different conditions are also discussed.

Supercontinuum generation, photonic crystal fiber

Preface.Introduction.Chapter 1. Selected Topics in Electromagnetic Wave Propagation.1.1. Maxwell's Equations and the Fundamental Fields.1.2. Electromagnetic Wave Propagation in Sourceless Media.1.3. Power Transmission.1.4. Group Velocity.1.5. Reflection and Transmission of Waves at Plane Interfaces.1.6. Material Resonances and Their Effects on Wave Propagation.Problems.References.Chapter 2. Symmetric Dielectric Slab Waveguides.2.1. Ray Analysis of the Slab Waveguides.2.2. Field Analysis of the Slab Waveguides.2.3. Solutions of the Eigenvalue Equations.2.4. Power Transmission and Confinement.2.5. Leaky Waves.2.6. Radiation Modes.2.7. Wave Propagation in Curved Slab Waveguides.Problems.References.Chapter 3. Weakly-Guiding Fibers with Step Index Profiles.3.1. Rays and Fields in the Step Index Fiber.3.2. Field Analysis of the Weakly-Guiding Fiber.3.3. Eigenvalue Equation for LP Modes.3.4. LP Mode Characteristics.3.5. Single Mode Fiber Parameters.3.6. Derivation of the General Step Index Fiber Modes.Problems.References.Chapter 4. Loss Mechanisms in Silica Fiber.4.1. Basic Loss Effects in Transmission.4.2. Fabrication of Silica Fibers.4.3. Intrinsic Loss.4.4. Extrinsic Loss.4.5. Bending Loss.4.6. Source-to-Fiber Coupling.Problems.References.Chapter 5. Dispersion.5.1. Pulse Propagation in Media Possessing Quadratic Dispersion.5.2. Material Dispersion.5.3. Dispersion in Optical Fiber.5.4. Chromatic Dispersion Compensation.5.5. Polarization Dispersion.5.6. System Considerations and Dispersion Measurement.Problems.References.Chapter 6. Special Purpose Index Profiles.6.1. Multimode Graded Index Fiber.6.2. Special Index Profile Optimization.Problems.References.Chapter 7. Nonlinear Effects in Fibers I: Non-Resonant Processes.7.1. Nonlinear Optics Fundamentals.7.2. Nonlinear Phase Modulation on Pulses.7.3. The Nonlinear Schrodinger Equation.7.4. Additional Non-Resonant Processes.Problems.References.Chapter 8. Nonlinear Effects in Fibers II: Resonant Processes and Amplification.8.1. Raman Scattering.8.2. Stimulated Brillouin Scattering.8.3. Rare-Earth-Doped Fiber Amplifiers.Problems.References.Appendix A: Properties of Bessel Functions.Appendix B: Notation.Index.

Fundamentals of optical fibers

A novel highly sensitive porous core-photonic crystal fiber (PC-PCF) has been designed and analyzed for detection of chemical analytes in the terahertz frequency range. The PC-PCF is designed using rectangular structured air holes in the core with a kagome structured cladding. The full vectorial finite-element method is used to tune the geometrical parameters and to characterize the fiber. Our results demonstrate a high relative chemical sensitivity with significantly lower confinement loss for different analytes. Moreover, the PCF shows near zero dispersion variation, high modal effective area, high birefringence, and high numerical aperture. The practical realization of the fiber is feasible with present fabrication techniques. Our optimized PCF has commercial applications in chemical sensing as well as applications in terahertz systems that require guided polarization preserving transmission.

A Novel Approach for Spectroscopic Chemical Identification Using Photonic Crystal Fiber in the Terahertz Regime

This paper proposes a hexagonal photonic crystal fiber (H-PCF) structure with high relative sensitivity for liquid sensing; in which both core and cladding are microstructures. Numerical investigation is carried out by employing the full vectorial finite element method (FEM). The analysis has been done in four stages of the proposed structure. The investigation shows that the proposed structure achieves higher relative sensitivity by increasing the diameter of the innermost ring air holes in the cladding. Moreover, placing a single channel instead of using a group of tiny channels increases the relative sensitivity effectively. Investigating the effects of different parameters, the optimized structure shows significantly higher relative sensitivity with a low confinement loss.

/pdf/design-and-optimization-of-photonic-crystal-fiber-for-liquid-2jvejkvtwa.pdf

Design and optimization of photonic crystal fiber for liquid sensing applications

In this article, a hybrid photonic crystal fiber has been proposed for chemical sensing. A FEM has been applied for numerical investigation of some propagation characteristics of the PCF at a wider wavelength from 0.7 to 1.7 µm. The geometrical parameters altered to determine the optimized values. The proposed PCF contains three rings of circular holes in the cladding where the core is formulated with microstructure elliptical holes. The simulation result reveals that our proposed PCF exhibits high sensitivity and low confinement loss for benzene, ethanol and water than the prior PCFs. We have also shown that our proposed PCF shows high birefringence for benzene 1.544 × 10−3, for ethanol 1.513 × 10−3 and for water 1.474 × 10−3 at λ = 1.33 µm. The proposed PCF is simple with three rings which can be used for the sensing applications of industrially valuable lower indexed chemicals.

/pdf/hybrid-photonic-crystal-fiber-in-chemical-sensing-143vpjx2rs.pdf

Hybrid photonic crystal fiber in chemical sensing.

A micro structure folded cladding porous shaped with circular air hole photonic crystal fiber (FP-PCF) is proposed and numerically investigated in a broader wavelength range from 1.4 µm to 1.64 µm (E+S+C+L+U) for chemical sensing purposes. Employing finite element method (FEM) with anisotropic perfectly matched layer (PML) various properties of the proposed FP-PCF are numerically inquired. Filling the hole of core with aqueous analyte ethanol (n = 1.354) and tuning different geometric parameters of the fiber, the sensitivity order of 64.19% and the confinement loss of 2.07 × 10- 5 dB/m are attained at 1.48 µm wavelength in S band. The investigated numerical simulation result strongly focuses on sensing purposes; because this fiber attained higher sensitivity with lower confinement loss over the operating wavelength. Measuring time of sensitivity, simultaneously confinement loss also inquired. It reflects that confinement loss is highly dependable on PML depth but not for sensitivity. Beside above properties numerical aperture (NA), nonlinearity, and effective area are also computed. This FP-PCF also performed as sensor for other alcohol series (methanol, propanol, butanol, pentanol). Optimized FP-PCF shows higher sensitivity and low confinement loss carrying high impact in the area of chemical as well as gas sensing purposes. Surely it is clear that install such type of sensor will flourish technology massively.

https://cyberleninka.org/article/n/1462119.pdf

Folded cladding porous shaped photonic crystal fiber with high sensitivity in optical sensing applications: Design and analysis

Flammable or poisonous gasses in the air are capable of destroying a geographical area of causing a fire, fulmination, and venomous exposure. This paper presents a micro-cored photonic crystal fiber based gas sensor for detecting colorless or toxic gasses and monitoring air pollution by measuring gas condensate components in production facilities. The numerical investigation of the proposed PCF takes place using the finite element method (FEM). The geometrical parameters of proposed PCF are varied to optimize and observe the dependence of guiding properties on them. According to simulated results, the high relative sensitivity of 53.07% is obtained at 1.33 μm wavelength for optimum parameters. In addition, high birefringence of the order 6.9 × 10− 3; lower confinement loss of 3.21 × 10− 6 dB/m is also gained at the same wavelength. Moreover, nonlinear coefficient, effective area, splice loss, V parameters and beat length are reported briefly.

https://cyberleninka.org/article/n/660654.pdf

Proposal of a gas sensor with high sensitivity, birefringence and nonlinearity for air pollution monitoring

In this paper, a novel polarization-maintaining single-mode photonic crystal fiber (PCF) has been suggested for terahertz (THz) transmission applications. The reported PCF has five layers of hexagonal cladding with two layers of porous core. The cladding and core territory of the PCF are constituted by circular and elliptical air cavities, accordingly acting as a dielectric medium. Different geometrical parameters of the proposed PCF including pitches and diameters of circular air holes with the major and minor axes of elliptical air cavities being varied with the optimized structure. Various effects on the proposed PCF such as eccentricity and porosity effects are also carefully investigated. The numerical process is investigated by one of the most popular methods, the finite element method (FEM). All numerical computational results have revealed the ultrahigh birefringence in the order of 1.19×10−02 as well as the ultralow bulk absorption material loss of 0.0689  cm−1 at the 1 THz activation frequency. Besides, the V-parameter is also investigated for checking the proposed fiber modality. The proposed single-mode porous core hexagonal PCF is expected to be useful for convenient broadband transmission and numerous applications in the areas of THz technology.

Sayed Asaduzzaman

Papers

Design and optimization of photonic crystal fiber for liquid sensing applications

Hybrid photonic crystal fiber in chemical sensing.

Folded cladding porous shaped photonic crystal fiber with high sensitivity in optical sensing applications: Design and analysis

Proposal of a gas sensor with high sensitivity, birefringence and nonlinearity for air pollution monitoring

Ultrahigh birefringence, ultralow material loss porous core single-mode fiber for terahertz wave guidance.