S
Sayomi Higa
Researcher at University of the Ryukyus
Publications - 9
Citations - 615
Sayomi Higa is an academic researcher from University of the Ryukyus. The author has contributed to research in topics: Gene & Ribosomal protein. The author has an hindex of 9, co-authored 9 publications receiving 557 citations. Previous affiliations of Sayomi Higa include University of Miyazaki.
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Journal ArticleDOI
The Human Ribosomal Protein Genes: Sequencing and Comparative Analysis of 73 Genes
Maki Yoshihama,Tamayo Uechi,Shuichi Asakawa,Kazuhiko Kawasaki,Seishi Kato,Sayomi Higa,Noriko Maeda,Shinsei Minoshima,Tatsuo Tanaka,Nobuyoshi Shimizu,Naoya Kenmochi,Naoya Kenmochi +11 more
TL;DR: Comparison of RP genes from humans, Drosophila melanogaster, Caenorhabditis elegans, and Saccharomyces cerevisiae revealed the coding sequences to be highly conserved, although gene size and the number of exons vary.
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Loss of ribosomal protein L11 affects zebrafish embryonic development through a p53-dependent apoptotic response.
TL;DR: The data indicate that ribosomal dysfunction due to the loss of L11 activates a p53-dependent checkpoint response to prevent improper embryonic development and suggest that an L11 deficiency in a model organism activates the p53 pathway.
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Deficiency of ribosomal protein S19 during early embryogenesis leads to reduction of erythrocytes in a zebrafish model of Diamond-Blackfan anemia
Tamayo Uechi,Yukari Nakajima,Anirban Chakraborty,Hidetsugu Torihara,Sayomi Higa,Naoya Kenmochi +5 more
TL;DR: The results indicate that rps19 is essential for hematopoietic differentiation during early embryogenesis, and the RPS19-deficient zebrafish will provide a valuable tool for investigating the molecular mechanisms of DBA development in humans.
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The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders.
Naoya Kenmochi,Tsutomu Suzuki,Tamayo Uechi,Mika Magoori,Mariko Kuniba,Sayomi Higa,Kimitsuna Watanabe,Tatsuo Tanaka +7 more
TL;DR: This map provides a basis for studying possible roles of MRP defects in mitochondrial disorders and compared the assigned positions with candidate regions for mendelian disorders and found certain genes that might be involved in particular diseases.
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The Human Ribosomal Protein L6 Gene in a Critical Region for Noonan Syndrome
TL;DR: The genomic structure of the human ribosomal protein L6 gene (RPL6) is determined and assigned it to the interval containing the Noonan syndrome locus and the position of RPL6 is refined, using two different radiation hybrid panels.