T
Tamayo Uechi
Researcher at University of Miyazaki
Publications - 24
Citations - 1178
Tamayo Uechi is an academic researcher from University of Miyazaki. The author has contributed to research in topics: Zebrafish & Ribosomal protein. The author has an hindex of 15, co-authored 24 publications receiving 957 citations. Previous affiliations of Tamayo Uechi include University of Tokyo & University of California, San Francisco.
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Loss of ribosomal protein L11 affects zebrafish embryonic development through a p53-dependent apoptotic response.
TL;DR: The data indicate that ribosomal dysfunction due to the loss of L11 activates a p53-dependent checkpoint response to prevent improper embryonic development and suggest that an L11 deficiency in a model organism activates the p53 pathway.
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Deficiency of ribosomal protein S19 during early embryogenesis leads to reduction of erythrocytes in a zebrafish model of Diamond-Blackfan anemia
Tamayo Uechi,Yukari Nakajima,Anirban Chakraborty,Hidetsugu Torihara,Sayomi Higa,Naoya Kenmochi +5 more
TL;DR: The results indicate that rps19 is essential for hematopoietic differentiation during early embryogenesis, and the RPS19-deficient zebrafish will provide a valuable tool for investigating the molecular mechanisms of DBA development in humans.
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Ribosomal protein gene knockdown causes developmental defects in zebrafish.
Tamayo Uechi,Yukari Nakajima,Akihiro Nakao,Hidetsugu Torihara,Anirban Chakraborty,Kunio Inoue,Naoya Kenmochi +6 more
TL;DR: It is found that knockdown of some RP genes resulted in phenotypes specific to each gene, with varying degrees of abnormality in the brain, body trunk, eyes, and ears at about 25 hours post fertilization.
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Loss of ribosomal RNA modification causes developmental defects in zebrafish
Sayomi Higa-Nakamine,Takeo Suzuki,Tamayo Uechi,Anirban Chakraborty,Yukari Nakajima,Mikako Nakamura,Naoko Hirano,Tsutomu Suzuki,Naoya Kenmochi +8 more
TL;DR: It is found that decreased snoRNA expression reduces the snoRNAs-guided methylation of the target nucleotides, which suggests that rRNA modifications play an essential role in vertebrate development.
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Loss of Function Mutations in RPL27 and RPS27 Identified by Whole-Exome Sequencing in Diamond-Blackfan Anaemia
RuNan Wang,Kenichi Yoshida,Kenichi Yoshida,Tsutomu Toki,Takafumi Sawada,Tamayo Uechi,Yusuke Okuno,Yusuke Okuno,Aiko Sato-Otsubo,Aiko Sato-Otsubo,Kazuko Kudo,Isamu Kamimaki,Rika Kanezaki,Yuichi Shiraishi,Kenichi Chiba,Hiroko Tanaka,Kiminori Terui,Tomohiko Sato,Yuji Iribe,Shouichi Ohga,Madoka Kuramitsu,Isao Hamaguchi,Akira Ohara,Junichi Hara,Kumiko Goi,Kousaku Matsubara,Kenichi Koike,Akira Ishiguro,Yasuhiro Okamoto,Kenichiro Watanabe,Hitoshi Kanno,Seiji Kojima,Satoru Miyano,Naoya Kenmochi,Seishi Ogawa,Seishi Ogawa,Etsuro Ito +36 more
TL;DR: Novel germline mutations of two ribosomal protein genes responsible for Diamond‐Blackfan anaemia are identified, further confirming the concept that mutations in ribosome protein genes lead to Diamond‐ blackfang anaemia.