S
Scott Graham
Researcher at University of Queensland
Publications - 3
Citations - 378
Scott Graham is an academic researcher from University of Queensland. The author has contributed to research in topics: Patched & Gene targeting. The author has an hindex of 2, co-authored 3 publications receiving 370 citations.
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Journal Article
Most germ-line mutations in the nevoid basal cell carcinoma syndrome lead to a premature termination of the patched protein, and no genotype-phenotype correlations are evident
Carol Wicking,Susan Shanley,Ian M. Smyth,Susan Gillies,Kylie Negus,Scott Graham,Graeme Suthers,Neva Haites,Matthew S. Edwards,Brandon J. Wainwright,Georgia Chenevix-Trench +10 more
TL;DR: The preponderance of truncation mutants in the germ line of NBCCS patients suggests that the developmental defects associated with the disorder are most likely due to haploinsufficiency, and the notion that PTCH may have a transport function is supported.
Journal ArticleDOI
Patched 1 conditional null allele in mice
Tammy Ellis,Ian M. Smyth,Ian M. Smyth,Emily Riley,Emily Riley,Scott Graham,Kate Elliot,Monica Narang,Monica Narang,Graham F. Kay,Carol Wicking,Carol Wicking,Brandon J. Wainwright,Brandon J. Wainwright +13 more
TL;DR: A conditional Ptc allele in mice is described which will have utility for the temporospatial ablation of Ptc function and is described as a conditional patched gene in mice.
MostGerm-Line Mutations intheNevoidBasal CellCarcinoma Syndrome Leadtoa Premature Termination ofthePATCHEDProtein, andNoGenotype-Phenotype Correlations AreEvident
TL;DR: The preponderance oftruncation mutants in thegermline ofNBCCSpatients suggests that the developmental defects associated with the development of nevoid basal cell carcinoma syndrome are most likely duetohaploinsufficiency.