S
Scott J. Lusher
Researcher at Merck & Co.
Publications - 18
Citations - 8190
Scott J. Lusher is an academic researcher from Merck & Co.. The author has contributed to research in topics: Androgen receptor & Nuclear receptor. The author has an hindex of 11, co-authored 18 publications receiving 5184 citations. Previous affiliations of Scott J. Lusher include Radboud University Nijmegen & Schering-Plough.
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Patent
N-substituted azetidine derivatives
TL;DR: In this article, N-substituted azetidine derivatives have been shown to have estrogen receptor alpha (ERa) antagonistic and selective estrogen receptor downregulating (SERD) activity in ER-positive breast cancer cells.
Journal ArticleDOI
Variable loss of functional activities of androgen receptor mutants in patients with androgen insensitivity syndrome
P. Elfferich,M.E. van Royen,D.J. van de Wijngaart,J. Trapman,Stenvert L. S. Drop,E.L.T. van den Akker,Scott J. Lusher,R. Bosch,Trevor Bunch,Ieuan A. Hughes,Adriaan B Houtsmuller,Martine Cools,Sultana M.H. Faradz,P.H. Bisschop,M.C.M. Bunck,Wilma Oostdijk,Hennie T. Brüggenwirth,Albert O. Brinkmann +17 more
TL;DR: The data show that molecular phenotyping based on 5 different functional assays matched in most (70%) but not all cases, although the clinical phenotype was associated with complete AIS.
Journal Article
Non-steroidal steroid receptor modulators.
TL;DR: In the following paragraphs non-steroidal ligands which have full or partial agonistic activity will be described for the following receptors: PR, GR, AR, LXR and FXR.
Journal ArticleDOI
Discovery and optimisation of a selective non-steroidal glucocorticoid receptor antagonist.
Angus R. Brown,Michael Bosies,Helen Cameron,John W. Clark,Angela Cowley,Mark Craighead,Moira A. Elmore,Alistair Firth,Richard Goodwin,Susan Goutcher,Grant Emma Jane,Morag Grassie,Simon James Anthony Grove,Niall M. Hamilton,Hannah Hampson,Alison Hillier,Koc-Kan Ho,Michael Kiczun,Celia Kingsbury,Steven G. Kultgen,Littlewood Peter Thomas Albert,Scott J. Lusher,Susan MacDonald,Lorraine McIntosh,Theresa McIntyre,Ashvin Mistry,J. Richard Morphy,Olaf Nimz,Michael Ohlmeyer,Jack Pick,Zoran Rankovic,Brad Sherborne,Alasdair Smith,Michael Speake,Gayle Spinks,Fiona Thomson,Lynn Watson,Mark Weston +37 more
TL;DR: High-throughput screening of 3.87 million compounds delivered a novel series of non-steroidal GR antagonists that allowed progression from a non-selective ligand with a poor ADMET profile to an orally bioavailable, selective, stable, glucocorticoid receptor antagonist.
Patent
Non steroidal glucocorticoid receptor modulators
Ralf Plate,G.J.R. Zaman,Pedro Harold Han Hermkens,Christiaan Gerardus Johannes Maria Jans,R.C. Buijsman,Man De Adrianus Petrus Antonius,Conti Paolo Giovanni Martino,Scott J. Lusher,Willem Hendrik Abraham Dokter +8 more
TL;DR: In this article, the present invention relates to compounds having general Formula (I) or a pharmaceutically acceptable salt thereof, which is defined as a compound having general formula (I).