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Angus R. Brown
Researcher at Organon International
Publications - 14
Citations - 375
Angus R. Brown is an academic researcher from Organon International. The author has contributed to research in topics: Solid-phase synthesis & Antagonist. The author has an hindex of 8, co-authored 14 publications receiving 356 citations. Previous affiliations of Angus R. Brown include Merck & Co..
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Journal ArticleDOI
Synthesis of Tertiary Amines Using a Polystyrene (REM) Resin
TL;DR: A range of tertiary amines was constructed using a “traceless” linker on a polystyrene resin (REM resin), starting from secondary amines, primary amine, and resin-bound “ammonia”.
Journal ArticleDOI
Discovery and SAR of org 24598-a selective glycine uptake inhibitor.
Angus R. Brown,Ian Craig Carlyle,John K. Clark,William Hamilton,Samuel George Gibson,George McGarry,Sandra McEachen,Rae Duncan Robertson,Simon Nicholas Thorn,Glenn Walker +9 more
TL;DR: The discovery of Org 24598, one of the first potent and selective inhibitors of the glycine transporter is discussed and in vitro structure-activity relationships (SARs) data for interaction of a ligand with this system is discussed.
Journal ArticleDOI
Solid Phase Synthesis
Journal ArticleDOI
Structural Basis for Agonism and Antagonism for a Set of Chemically Related Progesterone Receptor Modulators
Scott J. Lusher,Hans C.A. Raaijmakers,Diep Vu-Pham,Koen J. Dechering,Tsang Wai Lam,Angus R. Brown,Niall M. Hamilton,Olaf Nimz,Rolien Bosch,Ross McGuire,Arthur Oubrie,Jacob de Vlieg +11 more
TL;DR: Two new progesterone receptor ligand binding domain x-ray structures bound to compounds from a structurally related but functionally divergent series, which show different binding modes corresponding to their agonistic or antagonistic nature.
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Fragment-based discovery of 6-substituted isoquinolin-1-amine based ROCK-I inhibitors.
Peter C. Ray,Jane E. Wright,Julia M. Adam,Johnathan Bennett,Sylviane Boucharens,Darcey Black,Andrew J. Cook,Angus R. Brown,Ola Epemolu,D. S. Fletcher,Anders Haunso,Margaret Huggett,Philip Jones,Steven Laats,Amanda J. Lyons,Jordi Mestres,Jos de Man,Richard Morphy,Zoran Rankovic,Brad Sherborne,Lorcan Sherry,Nicole C.R. van Straten,Paul Westwood,Guido Z.R. Zaman +23 more
TL;DR: Fragment-based NMR screening of a small literature focused library led to identification of a historical thrombin/FactorXa building block, 17A, that was found to be a ROCK-I inhibitor.