S
Scott R. Macfarlane
Researcher at University of Strathclyde
Publications - 5
Citations - 1401
Scott R. Macfarlane is an academic researcher from University of Strathclyde. The author has contributed to research in topics: Receptor & Protein kinase C. The author has an hindex of 5, co-authored 5 publications receiving 1381 citations. Previous affiliations of Scott R. Macfarlane include Strathclyde Institute of Pharmacy and Biomedical Sciences.
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Journal Article
Proteinase-Activated Receptors
TL;DR: The role of thrombin in such processes as wound healing and the evidence implicating PAR-1 in vascular disorders and cancer are described and advances in the understanding ofPAR-1-mediated intracellular signaling and receptor desensitization are identified.
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Proteinase-activated receptor-2-mediated activation of stress-activated protein kinases and inhibitory kappa B kinases in NCTC 2544 keratinocytes.
Toru Kanke,Scott R. Macfarlane,Michael J. Seatter,Emma Davenport,Andrew Paul,Roderick C. McKenzie,Robin Plevin +6 more
TL;DR: This study shows for the first time proteinase-activated receptor-2-mediated stimulation of both SAP kinase and IKK signaling and differing roles for PKC isoforms in the regulation of each pathway.
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The role of intracellular Ca2+ in the regulation of proteinase-activated receptor-2 mediated nuclear factor kappa B signalling in keratinocytes.
Scott R. Macfarlane,Callum M. Sloss,Pamela Cameron,Toru Kanke,Roderick C. McKenzie,Robin Plevin +5 more
TL;DR: A predominant role for the InsP3/Ca2+ axis in the regulation of IKK signalling and NFκB transcriptional activation is suggested in skin epithelial cell line NCTC2544.
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The role of the C-terminal tail in protease-activated receptor-2-mediated Ca2+ signalling, proline-rich tyrosine kinase-2 activation, and mitogen-activated protein kinase activity.
Michael J. Seatter,Robert M. Drummond,Toru Kanke,Scott R. Macfarlane,Morley D. Hollenberg,Robin Plevin +5 more
TL;DR: A novel sequence within the PAR-2 C-terminus essential for InsP(3) generation and PYK-2 activity but not mitogen-activated protein kinase (MAPK) activation is identified.
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Intracellular signalling by the G‐protein coupled proteinase‐activated receptor (PAR) family
Scott R. Macfarlane,Robin Plevin +1 more
TL;DR: Activation of intracellular signalling pathways by the PAR family has received relatively little attention compared with the other aspects of their function, but signalling pathways closely linked to both cell proliferation and inflammation are described.